EM structure of MPEG-1 (L425K, alpha conformation) soluble pre-pore complex

Summary for 6U2J

EMDB information20620 20616 20617 20619 20621 20622 20623
DescriptorMacrophage-expressed gene 1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywordsmpeg-1/perforin-2, macpf, macrophage, pore forming proteins, immunity, immune system
Biological sourceHomo sapiens (Human)
Total number of polymer chains16
Total molecular weight1148348.11
Pang, S.S.,Bayly-Jones, C. (deposition date: 2019-08-20, release date: 2019-09-25, Last modification date: 2020-07-29)
Primary citation
Pang, S.S.,Bayly-Jones, C.,Radjainia, M.,Spicer, B.A.,Law, R.H.P.,Hodel, A.W.,Parsons, E.S.,Ekkel, S.M.,Conroy, P.J.,Ramm, G.,Venugopal, H.,Bird, P.I.,Hoogenboom, B.W.,Voskoboinik, I.,Gambin, Y.,Sierecki, E.,Dunstone, M.A.,Whisstock, J.C.
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10:4288-4288, 2019
PubMed: 31537793 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-019-12279-2
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers40 0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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PDB entries from 2020-11-25