6DDI

Crystal Structure of the human BRD2 BD1 bromodomain in complex with a Tetrahydroquinoline analogue

Summary for 6DDI

DescriptorBromodomain-containing protein 2, 4-{[(2S,4R)-1-acetyl-2-methyl-6-(1H-pyrazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]amino}benzonitrile, SULFATE ION, ... (6 entities in total)
Functional Keywordsbet, brd2, bromodomain, inhibitor, complex, transcription, transcription-inhibitor complex, transcription/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight49945.17
Authors
White, S.W.,Yun, M. (deposition date: 2018-05-10, release date: 2019-11-13)
Primary citation
White, S.W.,Yun, M.
Crystal Structure of the human BRD2 BD1 bromodomain in complex with a Tetrahydroquinoline analogue
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.17420 0.3% 5.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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