6DBC

Second bromodomain of Human BRD2 with a Tetrahydroquinoline analogue

Summary for 6DBC

DescriptorBromodomain-containing protein 2, 1,2-ETHANEDIOL, 1-[(2S,4R)-4-[(2-chlorophenyl)amino]-2-methyl-6-(1H-pyrazol-3-yl)-3,4-dihydroquinolin-1(2H)-yl]ethan-1-one, ... (4 entities in total)
Functional Keywordsbet, brd2, bromodomain, inhibitor, complex, transcription, transcription-inhibitor complex, transcription/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight14339.82
Authors
White, S.W.,Yun, M. (deposition date: 2018-05-03, release date: 2019-11-13)
Primary citation
White, S.W.,Yun, M.
Second bromodomain of Human BRD2 with a Tetrahydroquinoline analogue
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.05 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.132100 4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report