3.3 angstrom phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex

Summary for 6B3J

EMDB information7039
DescriptorGlucagon-like peptide 1 receptor, Exendin-P5, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
Functional Keywordsclass b g protein-coupled receptor, agonist-receptor-g protein ternary complex, glucagon-like peptide 1 receptor, active-state g protein-coupled receptor, signaling protein, phase plate, phase contrast, single particle cryo-em
Biological sourceHomo sapiens (Human)
Total number of polymer chains6
Total molecular weight168196.47
Primary citation
Liang, Y.L.,Khoshouei, M.,Glukhova, A.,Furness, S.G.B.,Zhao, P.,Clydesdale, L.,Koole, C.,Truong, T.T.,Thal, D.M.,Lei, S.,Radjainia, M.,Danev, R.,Baumeister, W.,Wang, M.W.,Miller, L.J.,Christopoulos, A.,Sexton, P.M.,Wootten, D.
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Nature, 555:121-125, 2018
PubMed: 29466332 (PDB entries with the same primary citation)
DOI: 10.1038/nature25773
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers400.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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