6AZ3

Cryo-EM structure of of the large subunit of Leishmania ribosome bound to paromomycin

This is a large structure.

Summary for 6AZ3

Related6AZ1
EMDB information7025 7024
Descriptorribosomal protein uL2, ribosomal protein uL3, ribosomal protein uL4, ... (54 entities in total)
Functional Keywordsleishmania, ribosome, aminoglycoside, paromomycin, ribosome-antibiotic complex, ribosome/antibiotic
Biological sourceLeishmania donovani
Total number of polymer chains50
Total molecular weight2119813.12
Authors
Shalev-Benami, M.,Zhang, Y.,Rozenberg, H.,Nobe, Y.,Taoka, M.,Matzov, D.,Zimmerman, E.,Bashan, A.,Isobe, T.,Jaffe, C.L.,Yonath, A.,Skiniotis, G. (deposition date: 2017-09-09, release date: 2017-12-06, Last modification date: 2017-12-13)
Primary citation
Shalev-Benami, M.,Zhang, Y.,Rozenberg, H.,Nobe, Y.,Taoka, M.,Matzov, D.,Zimmerman, E.,Bashan, A.,Isobe, T.,Jaffe, C.L.,Yonath, A.,Skiniotis, G.
Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Nat Commun, 8:1589-1589, 2017
PubMed: 29150609 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-017-01664-4
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone40.2%1.6%0.44MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation report