Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1

Summary for 6A60

Related6A5W 6A5X 6A5Y 6A5Z
DescriptorBile acid receptor, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha, ... (6 entities in total)
Functional Keywordsnuclear receptor heterodimer, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight58176.23
Wang, N.,Liu, J. (deposition date: 2018-06-25, release date: 2018-10-10, Last modification date: 2018-12-05)
Primary citation
Wang, N.,Zou, Q.,Xu, J.,Zhang, J.,Liu, J.
Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding
J. Biol. Chem., 293:18180-18191, 2018
PubMed: 30275017 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA118.004652
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2937 0.5% 10.4% 2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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