PanDDA analysis group deposition -- Crystal Structure of human ALAS2A in complex with Z31721798

Summary for 5QRC

Group depositionPanDDA analysis group deposition (G_1002078)
Descriptor5-aminolevulinate synthase, erythroid-specific, mitochondrial, PYRIDOXAL-5'-PHOSPHATE, 3-cyclohexyl-1-(morpholin-4-yl)propan-1-one, ... (4 entities in total)
Functional Keywordssgc - diamond i04-1 fragment screening, pandda, xchemexplorer, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight105220.72
Primary citation
Bezerra, G.A.,Foster, W.,Bailey, H.,Shrestha, L.,Krojer, T.,Talon, R.,Brandao-Neto, J.,Douangamath, A.,Nicola, B.B.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Brennan, P.E.,Yue, W.W.
PanDDA analysis group deposition
To Be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2436 0.1% 3.3% 2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution