PanDDA analysis group deposition -- Crystal Structure of BRD1 after initial refinement with no ligand modelled (structure 27)

Summary for 5PPQ

Group depositionPanDDA analysis group deposition of models of ground state datasets (G_1002023)
DescriptorBromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION, ... (4 entities in total)
Functional Keywordspandda, sgc - diamond i04-1 fragment screening, bromodomain, epigenetics, xchemexplorer, gene regulation
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  O95696
Total number of polymer chains2
Total molecular weight36720.62
Primary citation
Pearce, N.M.,Krojer, T.,Bradley, A.R.,Collins, P.,Nowak, R.P.,Talon, R.,Marsden, B.D.,Kelm, S.,Shi, J.,Deane, C.M.,von Delft, F.
A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8:15123-15123, 2017
PubMed: 28436492 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms15123
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21430 0.5% 1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-25