Paired helical filament in Alzheimer's disease brain

Summary for 5O3L

EMDB information3741
DescriptorMicrotubule-associated protein tau (1 entity in total)
Functional Keywordstau, amyloid, cross-beta, beta-helix, structural protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains10
Total molecular weight79401.41
Fitzpatrick, A.W.P.,Falcon, B.,He, S.,Murzin, A.G.,Murshudov, G.,Garringer, H.G.,Crowther, R.A.,Ghetti, B.,Goedert, M.,Scheres, S.H.W. (deposition date: 2017-05-24, release date: 2017-07-26, Last modification date: 2019-07-24)
Primary citation
Fitzpatrick, A.W.P.,Falcon, B.,He, S.,Murzin, A.G.,Murshudov, G.,Garringer, H.J.,Crowther, R.A.,Ghetti, B.,Goedert, M.,Scheres, S.H.W.
Cryo-EM structures of tau filaments from Alzheimer's disease.
Nature, 547:185-190, 2017
PubMed: 28678775 (PDB entries with the same primary citation)
DOI: 10.1038/nature23002
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers1000MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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PDB entries from 2020-11-25