5HKV

The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lincomycin

Summary for 5HKV

Related4WCE 4WFA 4WF9 4WFB
Descriptor23s ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ... (34 entities in total)
Functional Keywordsribosome, rna, lincomycin, antibiotics
Biological sourceStaphylococcus aureus subsp. aureus NCTC 8325
Total number of polymer chains27
Total molecular weight1364953.9
Authors
Yonath, A.,Matzov, D.,Eyal, Z.,Ben Hamou, R.,Zimmerman, E.,Rozenberg, H.,Bashan, A.,Fridman, M. (deposition date: 2016-01-14, release date: 2017-05-03, Last modification date: 2017-10-11)
Primary citation
Matzov, D.,Eyal, Z.,Benhamou, R.I.,Shalev-Benami, M.,Halfon, Y.,Krupkin, M.,Zimmerman, E.,Rozenberg, H.,Bashan, A.,Fridman, M.,Yonath, A.
Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus.
Nucleic Acids Res., 45:10284-10292, 2017
PubMed: 28973455 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkx658
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.66 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.234145.4%16.7%2.1%0.42MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report