5FZ6

Crystal structure of the catalytic domain of human JARID1B in complex with Maybridge fragment N05859b (ligand modelled based on PANDDA event map, SGC - Diamond I04-1 fragment screening)

Summary for 5FZ6

Related5FY4 5FY5 5FY7 5FY8 5FY9 5FYB 5FYC 5FYH 5FYI 5FYM 5FYS 5FYT 5FYU 5FYV 5FYY 5FYZ 5FZ0 5FZ1 5FZ3 5FZ4 5FZ7 5FZ8 5FZ9 5FZA 5FZB 5FZC 5FZD 5FZE 5FZF 5FZG 5FZH 5FZI 5FZK 5FZL 5FZM 5FZO
DescriptorLYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ... (10 entities in total)
Functional Keywordsoxidoreductase, jarid1b, plu1, fragment screening, structural genomics consortium, sgc, diamond i04-1, pandda
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus  Q9UGL1
Total number of polymer chains1
Total molecular weight56753.02
Authors
Primary citation
Nowak, R.,Krojer, T.,Johansson, C.,Kupinska, K.,Szykowska, A.,Pearce, N.,Talon, R.,Collins, P.,Gileadi, C.,Strain-Damerell, C.,Burgess-Brown, N.A.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,von Delft, F.,Brennan, P.E.,Oppermann, U.
Crystal Structure of the Catalytic Domain of Human Jarid1B in Complex with Maybridge Fragment N05859B (Ligand Modelled Based on Pandda Event Map, Sgc - Diamond I04-1 Fragment Screening)
To be Published,
Experimental method
X-RAY DIFFRACTION (2.33 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2206 0.2% 0.7% 2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171588
PDB entries from 2020-11-25