5A63

Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution.

Replaces:  4UPC

Summary for 5A63

EMDB information3061
DescriptorNicastrin, Presenilin-1, Gamma-secretase subunit APH-1A, ... (7 entities in total)
Functional Keywordshydrolase, cryo-em, human gamma-secretase, membrane protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total molecular weight178134.37
Authors
Bai, X.,Yan, C.,Yang, G.,Lu, P.,Ma, D.,Sun, L.,Zhou, R.,Scheres, S.H.W.,Shi, Y. (deposition date: 2015-06-24, release date: 2015-08-05, Last modification date: 2019-09-11)
Primary citation
Bai, X.,Yan, C.,Yang, G.,Lu, P.,Ma, D.,Sun, L.,Zhou, R.,Scheres, S.H.W.,Shi, Y.
An Atomic Structure of Human Gamma-Secretase
Nature, 525:212-, 2015
PubMed: 26280335 (PDB entries with the same primary citation)
DOI: 10.1038/NATURE14892
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (3.4 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers39 2.1% 13.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation report