4V8Z

Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex

This is a large structure.

Summary for 4V8Z

Related4BYL 4BYN 4BYO 4BYP 4BYQ 4BYR 4BYS
Integrates4BYT 4BYU 4BYV 4BYW 4BYX
EMDB information2422
Descriptor40S RIBOSOMAL PROTEIN S26-A, 40S RIBOSOMAL PROTEIN S27-A, 40S RIBOSOMAL PROTEIN S28-A, ... (89 entities in total)
Functional Keywordsribosome, ribosome initiation complex, initiator factor eif5b, single particle analysis
Biological sourceSACCHAROMYCES CEREVISIAE
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Total number of polymer chains85
Total molecular weight3331292.7
Authors
Fernandez, I.S.,Bai, X.C.,Hussain, T.,Kelley, A.C.,Lorsch, J.R.,Ramakrishnan, V.,Scheres, S.H.W. (deposition date: 2013-07-20, release date: 2014-07-09, Last modification date: 2019-12-11)
Primary citation
Fernandez, I.S.,Bai, X.C.,Hussain, T.,Kelley, A.C.,Lorsch, J.R.,Ramakrishnan, V.,Scheres, S.H.W.
Molecular architecture of a eukaryotic translational initiation complex.
Science, 342:1240585-1240585, 2013
PubMed: 24200810 (PDB entries with the same primary citation)
DOI: 10.1126/science.1240585
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (6.6 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone27 6.5% 21.2% 0.44MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
Download full validation report