4IBS

Human p53 core domain with hot spot mutation R273H (form I)

Summary for 4IBS

Related4IBQ 4IBT 4IBU 4IBV 4IBW 4IBY 4IBZ 4IJT
DescriptorCellular tumor antigen p53, ZINC ION, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsmetal-binding, loop-sheet-helix motif, transcription, activator, anti-oncogene, apoptosis, cell cycle, disease mutation, rescue mutation, tumor suppressor, dna binding protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm P04637
Total number of polymer chains4
Total molecular weight90269.84
Authors
Rozenberg, H.,Eldar, A.,Diskin-Posner, Y.,Shakked, Z. (deposition date: 2012-12-09, release date: 2013-08-14, Last modification date: 2017-11-15)
Primary citation
Eldar, A.,Rozenberg, H.,Diskin-Posner, Y.,Rohs, R.,Shakked, Z.
Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41:8748-8759, 2013
PubMed: 23863845 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkt630
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.78 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.182404.3%2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report