Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A

Summary for 3D09

Related3D05 3D06 3D07 3D08 3D0A
DescriptorCellular tumor antigen p53, ZINC ION (3 entities in total)
Functional Keywordsp53, mutant protein, loop-sheet-helix motif, acetylation, activator, alternative splicing, anti-oncogene, apoptosis, cell cycle, covalent protein-rna linkage, cytoplasm, disease mutation, dna-binding, endoplasmic reticulum, glycoprotein, host-virus interaction, li-fraumeni syndrome, metal-binding, methylation, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, ubl conjugation, zinc
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm P04637
Total number of polymer chains1
Total molecular weight22489.9
Rozenberg, H.,Suad, O.,Shakked, Z. (deposition date: 2008-05-01, release date: 2009-01-20, Last modification date: 2011-07-13)
Primary citation
Suad, O.,Rozenberg, H.,Brosh, R.,Diskin-Posner, Y.,Kessler, N.,Shimon, L.J.W.,Frolow, F.,Liran, A.,Rotter, V.,Shakked, Z.
Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385:249-265, 2009
PubMed: 18996393 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2008.10.063
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.266300 3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-12-02