Three dimensional structure of EPI-X4, a human albumin-derived peptide that regulates innate immunity through the CXCR4/CXCL12 chemotactic axis and antagonizes HIV-1 entry

Summary for 2N0X

DescriptorSerum albumin (1 entity in total)
Functional Keywordsantagonist, inhibitor peptide, peptide binding protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted P02768
Total number of polymer chains1
Total molecular weight1833.2
Perez-Castells, J.,Canales, A.,Jimenez-Barbero, J.,Gimenez-Gallego, G. (deposition date: 2015-03-18, release date: 2015-04-29, Last modification date: 2015-05-20)
Primary citation
Zirafi, O.,Kim, K.A.,Standker, L.,Mohr, K.B.,Sauter, D.,Heigele, A.,Kluge, S.F.,Wiercinska, E.,Chudziak, D.,Richter, R.,Moepps, B.,Gierschik, P.,Vas, V.,Geiger, H.,Lamla, M.,Weil, T.,Burster, T.,Zgraja, A.,Daubeuf, F.,Frossard, N.,Hachet-Haas, M.,Heunisch, F.,Reichetzeder, C.,Galzi, J.L.,Perez-Castells, J.,Canales-Mayordomo, A.,Jimenez-Barbero, J.,Gimenez-Gallego, G.,Schneider, M.,Shorter, J.,Telenti, A.,Hocher, B.,Forssmann, W.G.,Bonig, H.,Kirchhoff, F.,Munch, J.
Discovery and characterization of an endogenous CXCR4 antagonist.
Cell Rep, 11:737-747, 2015
PubMed: 25921529 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2015.03.061
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers50.4%21.1%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
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