2L6T

Efficacy of an HIV-1 entry inhibitor targeting the GP41 fusion peptide

Summary for 2L6T

Related2JNR 2L6S
DescriptorVIR-576 (1 entity in total)
Functional Keywordsanti-viral polypeptide, gp41 fusion peptide, fp1-24, antiviral protein
Total number of polymer chains1
Total molecular weight2252.69
Authors
Primary citation
Forssmann, W.G.,The, Y.H.,Stoll, M.,Adermann, K.,Albrecht, U.,Barlos, K.,Busmann, A.,Canales-Mayordomo, A.,Gimenez-Gallego, G.,Hirsch, J.,Jimenez-Barbero, J.,Meyer-Olson, D.,Munch, J.,Perez-Castells, J.,Standker, L.,Kirchhoff, F.,Schmidt, R.E.
Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide.
Sci Transl Med, 2:63re3-63re3, 2010
PubMed: 21178138 (PDB entries with the same primary citation)
DOI: 10.1126/scitranslmed.3001697
MImport into Mendeley
Experimental method
SOLUTION NMR
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Structure validation

ClashscoreRamachandran outliersSidechain outliers00.6%2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
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