1M49

Crystal Structure of Human Interleukin-2 Complexed with SP-1985

Summary for 1M49

Related1M47 1M48 1M4A 1M4B 1M4C
Descriptorinterleukin-2, 2-[2-(1-CARBAMIMIDOYL-PIPERIDIN-3-YL)-ACETYLAMINO]-3-{4-[2-(3-OXALYL-1H-INDOL-7-YL)ETHYL]-PHENYL}-PROPIONIC ACID METHYL ESTER (3 entities in total)
Functional Keywordscytokine, four-helix bundle, small molecule complex
Biological sourceHomo sapiens (human)
Cellular locationSecreted P60568
Total number of polymer chains2
Total molecular weight31995.22
Authors
Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C. (deposition date: 2002-07-02, release date: 2002-07-31, Last modification date: 2017-10-11)
Primary citation
Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C.
Binding of small molecules to an adaptive protein-protein interface
Proc.Natl.Acad.Sci.USA, 100:1603-1608, 2003
PubMed: 12582206 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.252756299
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.274903.1%10.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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