5PTA
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 154)
Descriptor:Bromodomain-containing protein 1, SODIUM ION, 1,2-ETHANEDIOL
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTB
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 155)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTC
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 156)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTE
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 157)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTF
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 158)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTG
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 159)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTH
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 160)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTJ
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 161)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTK
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 162)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTL
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 163)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTM
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 164)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTN
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 165)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTO
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 167)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTQ
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 168)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTR
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 169)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTS
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 170)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTT
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 171)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTU
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 172)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTV
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 173)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTW
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 174)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTX
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 175)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTY
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 176)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PTZ
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 177)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PU0
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 178)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017
5PU1
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PANDDA ANALYSIS GROUP DEPOSITION -- CRYSTAL STRUCTURE OF BRD1 AFTER INITIAL REFINEMENT WITH NO LIGAND MODELLED (STRUCTURE 179)
Descriptor:Bromodomain-containing protein 1, 1,2-ETHANEDIOL, SODIUM ION
Authors:Pearce, N.M., Krojer, T., Talon, R., Bradley, A.R., Fairhead, M., Sethi, R., Wright, N., MacLean, E., Collins, P., Brandao-Neto, J., Douangamath, A., Renjie, Z., Dias, A., Ng, J., Brennan, P.E., Cox, O., Bountra, C., Arrowsmith, C.H., Edwards, A., von Delft, F.
Deposit date:2017-02-07
Release date:2017-03-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density.
Nat Commun, 8, 2017