Mine: New entries

6O3J
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE HUMAN HIV-1 NEUTRALIZING ANTIBODY PGZL1 IN COMPLEX WITH ITS MPER PEPTIDE EPITOPE (REGION 671-683 OF HIV-1 GP41) AND PHOSPHATIDIC ACID (06:0 PA)
Descriptor:PGZL1 light chain, PGZL1 heavy chain, MPER peptide, ...
Authors:Irimia, A., Wilson, I.A.
Deposit date:2019-02-26
Release date:2019-12-04
Method:X-RAY DIFFRACTION (3.416 Å)
Cite:An MPER antibody neutralizes HIV-1 using germline features shared among donors
Nat Commun, 2019
6O3K
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CRYSTAL STRUCTURE OF THE UNBOUND FAB FRAGMENT OF THE HUMAN HIV-1 NEUTRALIZING ANTIBODY PGZL1.H4K3
Descriptor:PGZL1.H4K3 light chain, PGZL1.H4K3 heavy chain, GLYCEROL, ...
Authors:Irimia, A., Wilson, I.A.
Deposit date:2019-02-26
Release date:2019-12-04
Method:X-RAY DIFFRACTION (1.451 Å)
Cite:An MPER antibody neutralizes HIV-1 using germline features shared among donors
Nat Commun, 2019
6O3L
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE HUMAN HIV-1 NEUTRALIZING ANTIBODY PGZL1.H4K3 IN COMPLEX WITH ITS MPER PEPTIDE EPITOPE (REGION 671-683 OF HIV-1 GP41).
Descriptor:PGZL1.H4K3 light chain, PGZL1.H4K3 heavy chain, MPER peptide, ...
Authors:Irimia, A., Wilson, I.A.
Deposit date:2019-02-26
Release date:2019-12-04
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:An MPER antibody neutralizes HIV-1 using germline features shared among donors
Nat Commun, 2019
6O3U
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF THE HUMAN HIV-1 NEUTRALIZING ANTIBODY PGZL1.H4K3 IN COMPLEX WITH 06:0 PA
Descriptor:PGZL1.H4K3 light chain, PGZL1.H4K3 heavy chain, GLYCEROL, ...
Authors:Irimia, A., Wilson, I.A.
Deposit date:2019-02-27
Release date:2019-12-04
Method:X-RAY DIFFRACTION (3.105 Å)
Cite:An MPER antibody neutralizes HIV-1 using germline features shared among donors
Nat Commun, 2019
6O41
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CRYSTAL STRUCTURE OF THE UNBOUND PGZL1 GERMLINE FAB FRAGMENT (PGZL1_GVMDMJ)
Descriptor:germline PGZL1_gVmDmJ light chain, germline PGZL1_gVmDmJ heavy chain, Immunoglobulin G-binding protein G (DOMAIN III), ...
Authors:Irimia, A., Wilson, I.A.
Deposit date:2019-02-27
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.465 Å)
Cite:An MPER antibody neutralizes HIV-1 using germline features shared among donors
Nat Commun, 2019
6O42
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CRYSTAL STRUCTURE OF THE GERMLINE PGZL1 (PGZL1_GVMDMJ) FAB IN COMPLEX WITH MPER PEPTIDE EPITOPE.
Descriptor:PGZL1_gVmDmJ light chain, PGZL1_gVmDmJ heavy chain, MPER peptide, ...
Authors:Irimia, A., Wilson, I.A.
Deposit date:2019-02-27
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An MPER antibody neutralizes HIV-1 using germline features shared among donors
Nat Commun, 2019
6O5H
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THE EFFECT OF MODIFIER STRUCTURE ON THE ACTIVATION OF LEUKOTRIENE A4 HYDROLASE AMINOPEPTIDASE ACTIVITY.
Descriptor:Leukotriene A-4 hydrolase, 4-{4-[(4-methoxyphenyl)methyl]phenyl}-1,3-thiazol-2-amine, ZINC ION
Authors:Noble, S.M., Lee, K.H., Paige, M.
Deposit date:2019-03-03
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Effect of Modifier Structure on the Activation of Leukotriene A4Hydrolase Aminopeptidase Activity.
J.Med.Chem., 2019
6O5Y
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STRUCTURE OF HUMAN CYTOCHROME P450 1A1 WITH 5-AMINO-N-(5-((4R,5R)-4-AMINO-5-FLUOROAZEPAN-1-YL)-1-METHYL-1H-PYRAZOL-4-YL)-2-(2,6-DIFLUOROPHENYL)THIAZOLE-4-CARBOXAMIDE)
Descriptor:Cytochrome P450 1A1, PROTOPORPHYRIN IX CONTAINING FE, 5-amino-N-{5-[(4R,5R)-4-amino-5-fluoroazepan-1-yl]-1-methyl-1H-pyrazol-4-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide, ...
Authors:Bart, A.G., Scott, E.E.
Deposit date:2019-03-04
Release date:2019-12-04
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate.
Drug Metab.Dispos., 2019
6OB5
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COMPUTATIONALLY-DESIGNED, MODULAR SENSE/RESPONSE SYSTEM (S3-2D)
Descriptor:Maltodextrin-binding protein, Ankyrin Repeat Domain (AR), S3-2D variant, ...
Authors:Thompson, M.C., Glasgow, A.A., Huang, Y.M., Fraser, J.S., Kortemme, T.
Deposit date:2019-03-19
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.208 Å)
Cite:Computational design of a modular protein sense-response system.
Science, 366, 2019
6OM5
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STRUCTURE OF A HAEMOPHORE FROM HAEMOPHILUS HAEMOLYTICUS
Descriptor:haemophore, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION, ...
Authors:Torrado, M., Walshe, J.L., Mackay, J.P., Guss, J.M., Gell, D.A.
Deposit date:2019-04-18
Release date:2019-12-04
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae.
Mol.Microbiol., 2019
6PEB
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CRYSTAL STRUCTURE OF HUMAN NAMPT IN COMPLEX WITH NVP-LTM976
Descriptor:Nicotinamide phosphoribosyltransferase, N-{4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-3-(pyridin-3-yl)azetidine-1-carboxamide, PHOSPHATE ION
Authors:Weihofen, W.A.
Deposit date:2019-06-20
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT).
Acs Med.Chem.Lett., 10, 2019
6PEK
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STRUCTURE OF SPASTIN HEXAMER (SUBUNIT A-E) IN COMPLEX WITH SUBSTRATE PEPTIDE
Descriptor:Spastin, substrate peptide, TYR-GLU-TYR-GLU-TYR-GLU-TYR-GLU, ...
Authors:Han, H., Schubert, H.L., McCullough, J., Monroe, N., Sundquist, W.I., Hill, C.P.
Deposit date:2019-06-20
Release date:2019-12-04
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of the microtubule severing protein spastin bound to a glutamte-rich peptide implies a hand-over-hand mechanism of substrate translocation.
To Be Published
6PEN
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STRUCTURE OF SPASTIN HEXAMER (WHOLE MODEL) IN COMPLEX WITH SUBSTRATE PEPTIDE
Descriptor:Spastin, EYEYEYEYEY, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Han, H., Schubert, H.L., McCullough, J., Monroe, N., Sundquist, W.I., Hill, C.P.
Deposit date:2019-06-20
Release date:2019-12-04
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of the microtubule severing protein spastin bound to a glutamte-rich peptide implies a hand-over-hand mechanism of substrate translocation.
To Be Published
6PEQ
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GLUA2 IN COMPLEX WITH ITS AUXILIARY SUBUNIT CNIH3 - MAP LBD-TMD-C3 - WITH ANTAGONIST ZK200775 -WITHOUT NTD
Descriptor:Glutamate receptor 2, Protein cornichon homolog 3, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid, ...
Authors:Nakagawa, T.
Deposit date:2019-06-20
Release date:2019-12-04
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structures of the AMPA receptor in complex with its auxiliary subunit cornichon
Science, 2019
6POR
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ANTIMICROBIAL LASSO PEPTIDE UBONODIN
Descriptor:Ubonodin
Authors:Link, A.J., Cheung-Lee, W.L.
Deposit date:2019-07-05
Release date:2019-12-04
Method:SOLUTION NMR
Cite:Discovery of ubonodin, an antimicrobial lasso peptide active against members of the Burkholderia cepacia complex
To Be Published
6PU7
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HUMAN IDO1 IN COMPLEX WITH COMPOUND 17 (N-{2-[(4-{N-[(7S)-4-FLUOROBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL]-N'-HYDROXYCARBAMIMIDOYL}-1,2,5-OXADIAZOL-3-YL)SULFANYL]ETHYL}ACETAMIDE)
Descriptor:Indoleamine 2,3-dioxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, N-{2-[(4-{N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5-trien-7-yl]-N'-hydroxycarbamimidoyl}-1,2,5-oxadiazol-3-yl)sulfanyl]ethyl}acetamide
Authors:Lesburg, C.A.
Deposit date:2019-07-17
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.
Acs Med.Chem.Lett., 10, 2019
6PWC
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A COMPLEX STRUCTURE OF ARRESTIN-2 BOUND TO NEUROTENSIN RECEPTOR 1
Descriptor:Neurotensin receptor type 1, Neurotensin peptide, Beta-arrestin-1, ...
Authors:Yin, W., Li, Z., Jin, M., Yin, Y.-L., de Waal, P.W., Pal, K., Gao, X., He, Y., Gao, J., Wang, X., Zhang, Y., Zhou, H., Melcher, K., Jiang, Y., Cong, Y., Zhou, X.E., Yu, X., Xu, H.E.
Deposit date:2019-07-22
Release date:2019-12-04
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:A complex structure of arrestin-2 bound to a G protein-coupled receptor
To Be Published
6PWH
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CYSTAL STRUCTURE OF MYOTOXIN II FROM BOTHROPS MOOJENI CO-CRYSTALLIZED WITH VARESPLADIB (LY315920)
Descriptor:Basic phospholipase A2 homolog 2, ({3-[amino(oxo)acetyl]-1-benzyl-2-ethyl-1H-indol-4-yl}oxy)acetic acid, DIMETHYL SULFOXIDE
Authors:Salvador, G.H.M., Fontes, M.R.M.
Deposit date:2019-07-23
Release date:2019-12-04
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920).
Sci Rep, 9, 2019
6PYJ
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CRYSTAL STRUCTURE OF HLA-B*2705 IN COMPLEX WITH LRN, A SELF-PEPTIDE
Descriptor:HLA class I histocompatibility antigen, B-27 alpha chain, Beta-2-microglobulin, ...
Authors:Gras, S.
Deposit date:2019-07-30
Release date:2019-12-04
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation.
J.Biol.Chem., 2019
6PZD
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CRYSTAL STRUCTURE OF THE NEURAMINIDASE STABILIZATION MUTANT Y169AH FROM A/SHANGHAI/2/2013 (H7N9)
Descriptor:Neuraminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Zhu, X., Wilson, I.A.
Deposit date:2019-07-31
Release date:2019-12-04
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.
Cell Host Microbe, 2019
6PZE
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CRYSTAL STRUCTURE OF HUMAN NA-45 FAB IN COMPLEX WITH NEURAMINIDASE Y169AH MUTANT FROM A/SHANGHAI/2/2013 (H7N9)
Descriptor:Neuraminidase, NA-45 FAB LIGHT CHAIN, NA-45 FAB HEAVY CHAIN, ...
Authors:Zhu, X., Wilson, I.A.
Deposit date:2019-07-31
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.
Cell Host Microbe, 2019
6PZF
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CRYSTAL STRUCTURE OF HUMAN NA-63 FAB IN COMPLEX WITH NEURAMINIDASE FROM A/HUNAN/02650/2016(H7N9)
Descriptor:Neuraminidase, NA-63 Fab light chain, NA-63 Fab heavy chain, ...
Authors:Zhu, X., Wilson, I.A.
Deposit date:2019-07-31
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.
Cell Host Microbe, 2019
6PZG
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CRYSTAL STRUCTURE OF HUMAN NA-80 FAB
Descriptor:NA-80 Fab light chain, NA-80 Fab heavy chain
Authors:Zhu, X., Wilson, I.A.
Deposit date:2019-07-31
Release date:2019-12-04
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.
Cell Host Microbe, 2019
6PZH
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CRYSTAL STRUCTURE OF HUMAN NA-22 FAB
Descriptor:NA-22 Fab light chain, NA-22 Fab heavy chain
Authors:Zhu, X., Wilson, I.A.
Deposit date:2019-07-31
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.
Cell Host Microbe, 2019
6PZW
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CRYOEM DERIVED MODEL OF NA-22 FAB IN COMPLEX WITH N9 SHANGHAI2
Descriptor:Neuraminidase, NA-22 fragment antigen binding light chain, NA-22 fragment antigen binding heavy chain, ...
Authors:Ward, A.B., Turner, H.L., Zhu, X.
Deposit date:2019-08-01
Release date:2019-12-04
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies.
Cell Host Microbe, 2019