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冠狀病毒
冠狀病毒,2020. 由David S. Goodsell @ RCSB PDB原圖修改

最近爆發的新型冠狀病毒傳染病(Novel Coronavirus disease 2019: COVID-19)對全世界的人們都構成了嚴重威脅。 為了儘早了解新病毒(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)以開發出有效的抗病毒藥物,已經有很多科研人員開始了相關蛋白結構的研究,並且將所獲得結構數據存儲與PDB。 PDBj為用戶提供了COVID-19相關數據一覽的門戶頁面,並將於每週三更新當日新發佈的相關數據。

有關該病毒蛋白質的解說,請參見下面的“當月的分子”頁面。

“所有結構”標籤的頁面則逐一羅列了所有的數據,包括由同一研究組提交的系列數據群。 “代表性結構”標籤的頁面精選具有相同胺基酸序列的結構數據中的高分辨率數據,不重複選擇具有同一胺基酸序列的數據,即使該數據可能包含不同的配體。 “最新條目”標籤內包含本週新更新數據。

Created: 2020-03-11 (last edited: 4 weeks ago)2020-09-03
所有結構 (406)代表性結構 (175)最新條目 (16)
7K3T
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CRYSTAL STRUCTURE OF SARS-COV-2 MAIN PROTEASE (3CLPRO/MPRO) IN THE APO FORM AT 1.2 A RESOLUTION
Descriptor:3C-like proteinase, DIMETHYL SULFOXIDE
Authors:Andi, B., Kumaran, D., Kreitler, D.F., Soares, A.S., Shi, W., Jakoncic, J., Fuchs, M.R., Keereetaweep, J., Shanklin, J., McSweeney, S.
Deposit date:2020-09-13
Release date:2020-09-23
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Hepatitis C Virus NSP3/NSP4A Inhibitors as Promising Lead Compounds for the Design of New Covalent Inhibitors for SARS-CoV-2 3CLpro/Mpro Protease
To Be Published
7JZM
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SARS-COV-2 SPIKE IN COMPLEX WITH LCB3 (LOCAL REFINEMENT OF THE RBD AND LCB3)
Descriptor:LCB3, Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Park, Y.J., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-09-02
Release date:2020-09-23
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.
Science, 2020
7K1L
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CRYSTAL STRUCTURE OF NSP15 ENDORIBONUCLEASE FROM SARS COV-2 IN THE COMPLEX WITH URIDINE-2',3'-VANADATE
Descriptor:Uridylate-specific endoribonuclease, URIDINE-2',3'-VANADATE, ACETATE ION, ...
Authors:Kim, Y., Maltseva, N., Jedrzejczak, R., Endres, M., Welk, L., Chang, C., Michalska, K., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-09-07
Release date:2020-09-23
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-2',3'-Vanadate
To Be Published
6ZXN
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CRYO-EM STRUCTURE OF THE SARS-COV-2 SPIKE PROTEIN BOUND TO NEUTRALIZING NANOBODIES (TY1)
Descriptor:Spike glycoprotein, Nanobody Ty1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Hallberg, B.M., Das, H.
Deposit date:2020-07-30
Release date:2020-09-23
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Nat Commun, 11, 2020
7CAI
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SARS-COV-2 S TRIMER WITH TWO RBDS IN THE OPEN STATE AND COMPLEXED WITH TWO H014 FAB
Descriptor:Spike glycoprotein, Light chain of H014 Fab, Heavy chain of H014 Fab, ...
Authors:Zhe, L., Cao, L., Deng, Y., Sun, Y., Wang, N., Xie, L., Wang, Y., Rao, Z., Qin, C., Wang, X.
Deposit date:2020-06-08
Release date:2020-09-23
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody.
Science, 2020
7K40
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CRYSTAL STRUCTURE OF SARS-COV-2 MAIN PROTEASE (3CLPRO/MPRO) IN COMPLEX WITH COVALENT INHIBITOR BOCEPREVIR AT 1.35 A RESOLUTION
Descriptor:3C-like proteinase, boceprevir (bound form), DIMETHYL SULFOXIDE
Authors:Kumaran, D., Andi, B., Kreitler, D.F., Soares, A.S., Shi, W., Jakoncic, J., Fuchs, M.R., Keereetaweep, J., Shanklin, J., McSweeney, S.
Deposit date:2020-09-14
Release date:2020-09-23
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Hepatitis C Virus NSP3/NSP4A Inhibitors as Promising Lead Compounds for the Design of New Covalent Inhibitors for SARS-CoV-2 3CLpro/Mpro Protease
To Be Published
7JKV
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CRYSTAL STRUCTURE OF SARS-COV-2 MAIN PROTEASE IN COMPLEX WITH AN INHIBITOR GRL-2420
Descriptor:3C-like proteinase, N-[(2S)-1-({(1S,2S)-1-(1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, PENTAETHYLENE GLYCOL
Authors:Bulut, H., Hattori, S.I., Das, D., Murayama, K., Mitsuya, H.
Deposit date:2020-07-29
Release date:2020-09-23
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:A SARS-CoV-2's Main Protease-targeting Small-Compound GRL-2420 Completely Blocks the Infectivity and Cytopathicity of SARS-CoV-2
To Be Published
7A98
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH 3 ACE2 BOUND
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2
Authors:Benton, D.J., Wrobel, A.G., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-09-01
Release date:2020-09-23
Method:ELECTRON MICROSCOPY (5.4 Å)
Cite:Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion
Nature, 2020
7JZU
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SARS-COV-2 SPIKE IN COMPLEX WITH LCB1 (LOCAL REFINEMENT OF THE RBD AND LCB1)
Descriptor:LCB1, Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Park, Y.J., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-09-02
Release date:2020-09-23
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.
Science, 2020
7CAK
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SARS-COV-2 S TRIMER WITH THREE RBD IN THE OPEN STATE AND COMPLEXED WITH THREE H014 FAB
Descriptor:Spike glycoprotein, Light chain of H014 Fab, Heavy chain of H014 Fab, ...
Authors:Zhe, L., Cao, L., Deng, Y., Sun, Y., Wang, N., Xie, L., Wang, Y., Rao, Z., Qin, C., Wang, X.
Deposit date:2020-06-08
Release date:2020-09-23
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody.
Science, 2020
7K1O
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CRYSTAL STRUCTURE OF NSP15 ENDORIBONUCLEASE FROM SARS COV-2 IN THE COMPLEX WITH URIDINE-3',5'-DIPHOSPHATE
Descriptor:Uridylate-specific endoribonuclease, 1-(3,5-di-O-phosphono-alpha-L-xylofuranosyl)pyrimidine-2,4(1H,3H)-dione, 1,2-ETHANEDIOL
Authors:Kim, Y., Maltseva, N., Jedrzejczak, R., Endres, M., Welk, L., Chang, C., Michalska, K., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-09-08
Release date:2020-09-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-3',5'-Diphosphate
To Be Published
7D1O
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CRYSTAL STRUCTURE OF SARS-COV-2 MAIN PROTEASE WITH NARLAPREVIR
Descriptor:3C-like proteinase, (1R,2S,5S)-3-[N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl]-N-{(1S)-1-[(1R)-2-(cyclopropyla mino)-1-hydroxy-2-oxoethyl]pentyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide
Authors:Fu, L.F., Feng, Y., Qi, J.X.
Deposit date:2020-09-15
Release date:2020-09-23
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Crystal structure of SARS-Cov-2 main protease with narlaprevir
To Be Published
7AAP
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NSP7-NSP8-NSP12 SARS-COV2 RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH TEMPLATE:PRIMER DSRNA AND FAVIPIRAVIR-RTP
Descriptor:Non-structural protein 12, Non-structural protein 8, Non-structural protein 7, ...
Authors:Naydenova, K., Muir, K.W., Wu, L.F., Zhang, Z., Coscia, F., Peet, M., Castro-Hartman, P., Qian, P., Sader, K., Dent, K., Kimanius, D., Sutherland, J.D., Loewe, J., Barford, D., Russo, C.J.
Deposit date:2020-09-04
Release date:2020-09-23
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP
To Be Published
7JZL
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SARS-COV-2 SPIKE IN COMPLEX WITH LCB1 (2RBDS OPEN)
Descriptor:Spike glycoprotein, LCB1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Park, Y.J., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-09-02
Release date:2020-09-23
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.
Science, 2020
7JX6
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STRUCTURE OF THE SARS-COV-2 ORF8 ENCODED ACCESSORY PROTEIN
Descriptor:ORF8 protein, SODIUM ION
Authors:Hall, P.D., Nelson, C.A., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-08-26
Release date:2020-09-23
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Crystal Structure of the SARS-CoV-2 ORF8 Protein
To Be Published
7JZN
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SARS-COV-2 SPIKE IN COMPLEX WITH LCB3 (2RBDS OPEN)
Descriptor:Spike glycoprotein, LCB3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Park, Y.J., Veesler, D., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-09-02
Release date:2020-09-23
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:De novo design of picomolar SARS-CoV-2 miniprotein inhibitors.
Science, 2020
7CHC
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CRYSTAL STRUCTURE OF THE SARS-COV-2 S RBD IN COMPLEX WITH BD-629 FAB AND BD-368-2 FAB
Descriptor:BD-629 Fab H, IGK@ protein, Spike glycoprotein, ...
Authors:Du, S., Xiao, J.Y.
Deposit date:2020-07-05
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal structure of the SARS-CoV-2 S RBD in complex with BD-629 Fab and BD-368-2 Fab
To Be Published
7JZ0
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CRYSTAL STRUCTURE OF SARS-COV-2 NSP16/10 HETERODIMER IN COMPLEX WITH (M7GPPPA2M)PUPUPAPAPA (CAP-1) AND S-ADENOSYL-L-HOMOCYSTEINE (SAH).
Descriptor:2'-O-methyltransferase, Non-structural protein 10, RNA (5'-D(*(M7G))-R(P*(A2M)P*UP*U)-3'), ...
Authors:Minasov, G., Shuvalova, L., Rosas-Lemus, M., Kiryukhina, O., Brunzelle, J.S., Satchell, K.J.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-09-01
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA2m)pUpUpApApA (Cap-1) and S-Adenosyl-L-homocysteine (SAH).
To Be Published
7CH4
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CRYSTAL STRUCTURE OF THE SARS-COV-2 S RBD IN COMPLEX WITH BD-604 FAB
Descriptor:BD-604 Fab H, BD-604 Fab L, Spike glycoprotein
Authors:Du, S., Xiao, J.Y.
Deposit date:2020-07-05
Release date:2020-09-16
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Crystal structure of the SARS-CoV-2 S RBD in complex with BD-604 Fab
To Be Published
7A91
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DISSOCIATED S1 DOMAIN OF SARS-COV-2 SPIKE BOUND TO ACE2 (NON-UNIFORM REFINEMENT)
Descriptor:Angiotensin-converting enzyme 2, Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Benton, D.J., Wrobel, A.G., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-09-01
Release date:2020-09-16
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Receptor Binding and Priming of SARS-CoV-2 Spike for Membrane Fusion
To be published
7CH5
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CRYSTAL STRUCTURE OF THE SARS-COV-2 S RBD IN COMPLEX WITH BD-629 FAB
Descriptor:BD-629 Fab H, BD-629 Fab L, Spike glycoprotein
Authors:Du, S., Xiao, J.Y.
Deposit date:2020-07-05
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the SARS-CoV-2 S RBD in complex with BD-629 Fab
To Be Published
7A5R
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COMPLEX OF SARS-COV-2 SPIKE AND CR3022 FAB (NON-UNIFORM REFINEMENT)
Descriptor:CR3022 Fab Heavy Chain, CR3022 Fab Light Chain, Spike glycoprotein, ...
Authors:Wrobel, A.G., Benton, D.J., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-08-21
Release date:2020-09-16
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein
To be published
7A95
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH 1 ACE2 BOUND AND 1 RBD ERECT IN CLOCKWISE DIRECTION
Descriptor:Spike glycoprotein, Angiotensin-converting enzyme 2
Authors:Benton, D.J., Wrobel, A.G., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-09-01
Release date:2020-09-16
Last modified:2020-09-23
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion
Nature, 2020
7A93
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SARS-COV-2 SPIKE GLYCOPROTEIN WITH 2 RBDS ERECT
Descriptor:Spike glycoprotein
Authors:Benton, D.J., Wrobel, A.G., Rosenthal, P.B., Gamblin, S.J.
Deposit date:2020-09-01
Release date:2020-09-16
Last modified:2020-09-23
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion
Nature, 2020
7CHF
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CRYSTAL STRUCTURE OF THE SARS-COV-2 RBD IN COMPLEX WITH BD-604 FAB AND BD-368-2 FAB
Descriptor:BD-604 Fab heavy chain, BD-604 Fab light chain, SARS-coV-2 Receptor Binding Domain, ...
Authors:Xiao, J., Zhu, Q.
Deposit date:2020-07-05
Release date:2020-09-16
Method:X-RAY DIFFRACTION (2.674 Å)
Cite:Crystal structure of the SARS-CoV-2 RBD in complex with BD-604 Fab and BD-368-2 Fab
To Be Published
169117
數據於2020-09-23公開中