Author results

6CXO
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COMPLEMENT COMPONENT-9
Descriptor:Complement component C9, ZINC ION, CALCIUM ION, ...
Authors:Law, R.H.P., Spicer, B.A., Caradoc-Davies, T.T.
Deposit date:2018-04-03
Release date:2018-09-05
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
Nat Commun, 9, 2018
6DLW
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COMPLEMENT COMPONENT POLYC9
Descriptor:Complement component C9, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
Authors:Dunstone, M.A., Spicer, B.A., Law, R.H.P.
Deposit date:2018-06-03
Release date:2018-09-12
Last modified:2020-01-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:The first transmembrane region of complement component-9 acts as a brake on its self-assembly.
Nat Commun, 9, 2018
4V2T
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MEMBRANE EMBEDDED PLEUROTOLYSIN PORE WITH 13 FOLD SYMMETRY
Descriptor:PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N., Kondos, S.C., Farabella, I., Law, R.H.P., Reboul, C.F., Caradoc-Davies, T.T., Spicer, B.A., Kleifeld, O., Perugini, M., Ekkel, S., Hatfaludi, T., Oliver, K., Hotze, E.M., Tweten, R.K., Whisstock, J.C., Topf, M., Dunstone, M.A., Saibil, H.R.
Deposit date:2014-10-15
Release date:2015-02-18
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3A
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MEMBRANE BOUND PLEUROTOLYSIN PREPORE (TMH1 LOCK) TRAPPED WITH ENGINEERED DISULPHIDE CROSS-LINK
Descriptor:PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N., Kondos, S.C., Farabella, I., Law, R.H.P., Reboul, C.F., CaradocDavies, T.T., Spicer, B.A., Kleifeld, O., Perugini, M., Ekkel, S., Hatfaludi, T., Oliver, K., Hotze, E.M., Tweten, R.K., Whisstock, J.C., Topf, M., Dunstone, M.A., Saibil, H.R.
Deposit date:2014-10-17
Release date:2015-02-18
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (15 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3M
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MEMBRANE BOUND PLEUROTOLYSIN PREPORE (TMH2 HELIX LOCK) TRAPPED WITH ENGINEERED DISULPHIDE CROSS-LINK
Descriptor:PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N., Kondos, S.C., Farabella, I., Law, R.H.P., Reboul, C.F., Caradoc-Davies, T.T., Spicer, B.A., Kleifeld, O., Perugini, M., Ekkel, S., Hatfaludi, T., Oliver, K., Hotze, E.M., Tweten, R.K., Whisstock, J.C., Topf, M., Dunstone, M.A., Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (17 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4V3N
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MEMBRANE BOUND PLEUROTOLYSIN PREPORE (TMH2 STRAND LOCK) TRAPPED WITH ENGINEERED DISULPHIDE CROSS-LINK
Descriptor:PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N., Kondos, S.C., Farabella, I., Law, R.H.P., Reboul, C.F., Caradoc-Davies, T.T., Spicer, B.A., Kleifeld, O., Perugini, M., Ekkel, S., Hatfaludi, T., Oliver, K., Hotze, E.M., Tweten, R.K., Whisstock, J.C., Topf, M., Dunstone, M.A., Saibil, H.R.
Deposit date:2014-10-20
Release date:2015-02-18
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
5FMW
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THE POLY-C9 COMPONENT OF THE COMPLEMENT MEMBRANE ATTACK COMPLEX
Descriptor:POLYC9
Authors:Dudkina, N.V., Spicer, B.A., Reboul, C.F., Conroy, P.J., Lukoyanova, N., Elmlund, H., Law, R.H.P., Ekkel, S.M., Kondos, S.C., Goode, R.J.A., Ramm, G., Whisstock, J.C., Saibil, H.R., Dunstone, M.A.
Deposit date:2015-11-10
Release date:2016-02-17
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Structure of the Poly-C9 Component of the Complement Membrane Attack Complex
Nat.Commun., 7, 2016
4OEB
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STRUCTURE OF MEMBRANE BINDING PROTEIN PLEUROTOLYSIN A FROM PLEUROTUS OSTREATUS
Descriptor:Pleurotolysin A, SULFATE ION
Authors:Dunstone, M.A., Caradoc-Davies, T.T., Whisstock, J.C., Law, R.H.P.
Deposit date:2014-01-12
Release date:2015-02-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4OEJ
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STRUCTURE OF MEMBRANE BINDING PROTEIN PLEUROTOLYSIN B FROM PLEUROTUS OSTREATUS
Descriptor:Pleurotolysin B, ACETATE ION, GLYCEROL, ...
Authors:Dunstone, M.A., Caradoc-Davies, T.T., Whisstock, J.C., Law, R.H.P.
Deposit date:2014-01-13
Release date:2015-02-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
4OV8
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CRYSTAL STRUCTURE OF THE TMH1-LOCK MUTANT OF THE MATURE FORM OF PLEUROTOLYSIN B
Descriptor:Pleurotolysin B, SULFATE ION, CHLORIDE ION, ...
Authors:Kondos, S.C., Law, R.H.P., Whisstock, J.C., Dunstone, M.A.
Deposit date:2014-02-20
Release date:2015-02-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin
Plos Biol., 13, 2015
6U23
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EM STRUCTURE OF MPEG-1(W.T.) SOLUBLE PRE-PORE
Descriptor:Macrophage-expressed gene 1 protein, N-ACETYL-D-GLUCOSAMINE
Authors:Pang, S.S., Bayly-Jones, C.
Deposit date:2019-08-19
Release date:2019-09-25
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2J
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EM STRUCTURE OF MPEG-1 (L425K, ALPHA CONFORMATION) SOLUBLE PRE-PORE COMPLEX
Descriptor:Macrophage-expressed gene 1 protein, N-ACETYL-D-GLUCOSAMINE
Authors:Pang, S.S., Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (2.37 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2K
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EM STRUCTURE OF MPEG-1 (L425K, ALPHA CONFORMATION) SOLUBLE PRE-PORE COMPLEX
Descriptor:Macrophage-expressed gene 1 protein, N-ACETYL-D-GLUCOSAMINE
Authors:Pang, S.S., Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2L
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EM STRUCTURE OF MPEG-1 (L425K, BETA CONFORMATION) SOLUBLE PRE-PORE COMPLEX
Descriptor:Macrophage-expressed gene 1 protein, N-ACETYL-D-GLUCOSAMINE
Authors:Pang, S.S., Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (2.83 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019
6U2W
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EM STRUCTURE OF MPEG-1(L425K) PRE-PORE COMPLEX BOUND TO LIPOSOME
Descriptor:Macrophage-expressed gene 1 protein, N-ACETYL-D-GLUCOSAMINE
Authors:Pang, S.S., Bayly-Jones, C.
Deposit date:2019-08-20
Release date:2019-09-25
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1.
Nat Commun, 10, 2019