Author results

1J5O
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CRYSTAL STRUCTURE OF MET184ILE MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DOUBLE STRANDED DNA TEMPLATE-PRIMER
Descriptor:5'-D(*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*C)-3', 5'-D(*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*GP*CP*GP*CP*CP*A)-3', Reverse transcriptase, ...
Authors:Sarafianos, S.G., Das, K., Arnold, E.
Deposit date:2002-05-24
Release date:2002-06-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QE1
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CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE
Descriptor:REVERSE TRANSCRIPTASE, SUBUNIT P66, SUBUNIT P51
Authors:Sarafianos, S.G., Das, K., Ding, J., Hughes, S.H., Arnold, E.
Deposit date:1999-07-12
Release date:1999-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids.
Proc.Natl.Acad.Sci.USA, 96, 1999
1HYS
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA
Descriptor:5'-R(*UP*CP*AP*GP*CP*CP*AP*CP*UP*UP*UP*UP*UP*AP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3', 5'-D(*CP*TP*TP*TP*TP*CP*TP*TP*TP*TP*AP*AP*AP*AP*AP*GP*TP*GP*GP*CP*TP*G)-3', HIV-1 REVERSE TRANSCRIPTASE, ...
Authors:Sarafianos, S.G., Das, K., Tantillo, C., Clark Jr., A.D., Ding, J., Whitcomb, J., Boyer, P.L., Hughes, S.H., Arnold, E.
Deposit date:2001-01-22
Release date:2001-03-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.
EMBO J., 20, 2001
1N5Y
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HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO POST-TRANSLOCATION AZTMP-TERMINATED DNA (COMPLEX P)
Descriptor:5'-D(*AP*TP*GP*C*TP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3', REVERSE TRANSCRIPTASE, ...
Authors:Sarafianos, S.G., Clark Jr., A.D., Das, K., Tuske, S., Birktoft, J.J., Ilankumaran, P., Ramesha, A.R., Sayer, J.M., Jerina, D.M., Boyer, P.L., Hughes, S.H., Arnold, E.
Deposit date:2002-11-07
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of HIV-1 Reverse Transcriptase with Pre-Translocation and Post-Translocation AZTMP-Terminated DNA
Embo J., 21, 2002
1N6Q
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HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO PRE-TRANSLOCATION AZTMP-TERMINATED DNA (COMPLEX N)
Descriptor:5'-D(*AP*T*GP*CP*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*AP*(ATM))-3', Reverse Transcriptase, ...
Authors:Sarafianos, S.G., Clark Jr., A.D., Das, K., Tuske, S., Birktoft, J.J., Ilankumaran, I., Ramesha, A.R., Sayer, J.M., Jerina, D.M., Boyer, P.L., Hughes, S.H., Arnold, E.
Deposit date:2002-11-11
Release date:2003-01-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of HIV-1 Reverse Transcriptase with Pre- and Post-translocation AZTMP-terminated DNA
Embo J., 21, 2002
3NTC
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CRYSTAL STRUCTURE OF KD-247 FAB, AN ANTI-V3 ANTIBODY THAT INHIBITS HIV-1 ENTRY
Descriptor:Fab light chain, Fab heavy chain, SULFATE ION, ...
Authors:Sarafianos, S.G., Kirby, K.A.
Deposit date:2010-07-03
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of KD-247 Fab, an anti-V3 antibody that inhibits HIV-1 Entry
To be Published
2I5J
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH DHBNH, AN RNASE H INHIBITOR
Descriptor:Reverse transcriptase/ribonuclease H P66 subunit, Reverse transcriptase/ribonuclease H P51 subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ...
Authors:Himmel, D.M., Sarafianos, S.G., Knight, J.L., Levy, R.M., Arnold, E.
Deposit date:2006-08-24
Release date:2006-12-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.
Acs Chem.Biol., 1, 2006
1T03
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HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO TENOFOVIR TERMINATED TEMPLATE-PRIMER (COMPLEX P)
Descriptor:Synthetic oligonucleotide template, Synthetic oligonucleotide primer, POL polyprotein, ...
Authors:Tuske, S., Sarafianos, S.G., Ding, J., Arnold, E.
Deposit date:2004-04-07
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
Nat.Struct.Mol.Biol., 11, 2004
1T05
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HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO TEMPLATE-PRIMER WITH TENOFOVIR-DIPHOSPHATE BOUND AS THE INCOMING NUCLEOTIDE SUBSTRATE
Descriptor:oligonucleotide template, oligonucleotide primer, POL polyprotein, ...
Authors:Tuske, S., Sarafianos, S.G., Ding, J., Arnold, E.
Deposit date:2004-04-07
Release date:2004-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir
Nat.Struct.Mol.Biol., 11, 2004
1ZYR
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STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC STREPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase subunit beta' chain, ...
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark, A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-10
Release date:2005-09-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
2CW0
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME AT 3.3 ANGSTROMS RESOLUTION
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Tuske, S., Sarafianos, S.G., Wang, X., Hudson, B., Sineva, E., Mukhopadhyay, J., Birktoft, J.J., Leroy, O., Ismail, S., Clark Jr., A.D., Dharia, C., Napoli, A., Laptenko, O., Lee, J., Borukhov, S., Ebright, R.H., Arnold, E.
Deposit date:2005-06-15
Release date:2005-09-20
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005
3KLE
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CRYSTAL STRUCTURE OF AZT-RESISTANT HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO A DSDNA WITH A BOUND EXCISION PRODUCT, AZTPPPPA
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, DNA (25-MER), ...
Authors:Tu, X., Das, K., Sarafianos, S.G., Arnold, E.
Deposit date:2009-11-07
Release date:2010-09-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis of HIV-1 resistance to AZT by excision.
Nat.Struct.Mol.Biol., 17, 2010
3KLF
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CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO A DSDNA WITH A BOUND EXCISION PRODUCT, AZTPPPPA
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, DNA (5'-D(*AP*T*GP*CP*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ...
Authors:Tu, X., Das, K., Sarafianos, S.G., Arnold, E.
Deposit date:2009-11-07
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural basis of HIV-1 resistance to AZT by excision.
Nat.Struct.Mol.Biol., 17, 2010
3KLG
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CRYSTAL STRUCTURE OF AZT-RESISTANT HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO PRE-TRANSLOCATION AZTMP-TERMINATED DNA (COMPLEX N)
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, DNA (5'-D(*AP*T*GP*CP*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ...
Authors:Tu, X., Sarafianos, S.G., Arnold, E.
Deposit date:2009-11-07
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Structural basis of HIV-1 resistance to AZT by excision.
Nat.Struct.Mol.Biol., 17, 2010
3KLH
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CRYSTAL STRUCTURE OF AZT-RESISTANT HIV-1 REVERSE TRANSCRIPTASE CROSSLINKED TO POST-TRANSLOCATION AZTMP-TERMINATED DNA (COMPLEX P)
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, monoclonal antibody, ...
Authors:Tu, X., Sarafianos, S.G., Arnold, E.
Deposit date:2009-11-07
Release date:2010-09-22
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of HIV-1 resistance to AZT by excision.
Nat.Struct.Mol.Biol., 17, 2010
3KLI
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CRYSTAL STRUCTURE OF UNLIGANDED AZT-RESISTANT HIV-1 REVERSE TRANSCRIPTASE
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT
Authors:Tu, X., Sarafianos, S.G., Arnold, E.
Deposit date:2009-11-08
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural basis of HIV-1 resistance to AZT by excision.
Nat.Struct.Mol.Biol., 17, 2010
3P1G
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CRYSTAL STRUCTURE OF THE XENOTROPIC MURINE LEUKEMIA VIRUS-RELATED VIRUS (XMRV) RNASE H DOMAIN
Descriptor:Xenotropic Murine Leukemia Virus-Related Virus (XMRV) RNase H Domain, MAGNESIUM ION
Authors:Kirby, K.A., Sarafianos, S.G.
Deposit date:2010-09-30
Release date:2010-10-13
Last modified:2012-04-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Inhibition Studies of the RNase H Function of Xenotropic Murine Leukemia Virus-Related Virus Reverse Transcriptase.
Antimicrob.Agents Chemother., 56, 2012
4DG1
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) WITH POLYMORPHISM MUTATION K172A AND K173A
Descriptor:Reverse Transcriptase P66 subunit, Reverse Transcriptase P51 subunit, MAGNESIUM ION, ...
Authors:Tu, X., Kirby, K.A., Marchand, B., Sarafianos, S.G.
Deposit date:2012-01-24
Release date:2012-06-20
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors.
J.Biol.Chem., 287, 2012
4XFX
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STRUCTURE OF THE NATIVE FULL-LENGTH HIV-1 CAPSID PROTEIN
Descriptor:HIV-1 capsid protein, IODIDE ION, CHLORIDE ION
Authors:Gres, A.T., Kirby, K.A., Sarafianos, S.G.
Deposit date:2014-12-29
Release date:2015-06-10
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.
Science, 349, 2015
4XFY
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STRUCTURE OF THE NATIVE FULL-LENGTH DEHYDRATED HIV-1 CAPSID PROTEIN
Descriptor:HIV-1 capsid protein, CHLORIDE ION, PENTAETHYLENE GLYCOL
Authors:Gres, A.T., Kirby, K.A., Sarafianos, S.G.
Deposit date:2014-12-29
Release date:2015-06-10
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.
Science, 349, 2015
4XFZ
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STRUCTURE OF THE NATIVE FULL-LENGTH HIV-1 CAPSID PROTEIN IN COMPLEX WITH PF-3450074 (PF74)
Descriptor:HIV-1 capsid protein, IODIDE ION, CHLORIDE ION, ...
Authors:Gres, A.T., Kirby, K.A., Sarafianos, S.G.
Deposit date:2014-12-29
Release date:2015-06-10
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.
Science, 349, 2015
5HBM
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CRYSTAL STRUCTURE OF A DIHYDROXYCOUMARIN RNASE H ACTIVE-SITE INHIBITOR IN COMPLEX WITH HIV-1 REVERSE TRANSCRIPTASE
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, ...
Authors:Kirby, K.A., Sarafianos, S.G.
Deposit date:2015-12-31
Release date:2016-02-24
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (3.043 Å)
Cite:Crystal Structure of a Dihydroxycoumarin RNase H Active-Site Inhibitor in Complex with HIV-1 Reverse Transcriptase
To Be Published
5J1E
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CRYSTAL STRUCTURE OF A HYDROXYPYRIDONE CARBOXYLIC ACID ACTIVE-SITE RNASE H INHIBITOR IN COMPLEX WITH HIV REVERSE TRANSCRIPTASE
Descriptor:HIV-1 REVERSE TRANSCRIPTASE P66 DOMAIN, HIV-1 REVERSE TRANSCRIPTASE P51 DOMAIN, MAGNESIUM ION, ...
Authors:Kirby, K.A., Sarafianos, S.G.
Deposit date:2016-03-29
Release date:2016-06-15
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H.
J.Med.Chem., 59, 2016
5J2M
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HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DNA AND EFDA-TRIPHOSPHATE, A TRANSLOCATION-DEFECTIVE RT INHIBITOR
Descriptor:HIV-1 reverse transcriptase p51 subunit, DNA (5'-D(*AP*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*G)-3'), DNA (27-MER), ...
Authors:Salie, Z.L., Kirby, K.A., Sarafianos, S.G.
Deposit date:2016-03-29
Release date:2016-08-03
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.432 Å)
Cite:Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).
Proc.Natl.Acad.Sci.USA, 113, 2016
5J2N
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HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DNA THAT HAS INCORPORATED EFDA-MP AT THE P-(POST-TRANSLOCATION) SITE AND DTMP AT THE N-(PRE-TRANSLOCATION) SITE
Descriptor:reverse transcriptase, p66 domain, p51 domain, ...
Authors:Salie, Z.L., Kirby, K.A., Sarafianos, S.G.
Deposit date:2016-03-29
Release date:2016-08-03
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.896 Å)
Cite:Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).
Proc.Natl.Acad.Sci.USA, 113, 2016
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数据于2020-11-25公开中