Author results

2JNR
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DISCOVERY AND OPTIMIZATION OF A NATURAL HIV-1 ENTRY INHIBITOR TARGETING THE GP41 FUSION PEPTIDE
Descriptor:VIR165, ENV polyprotein
Authors:Munch, J., Standker, L., Adermann, K., Schulz, A., Pohlmann, S., Chaipan, C., Biet, T., Peters, T., Meyer, B., Wilhelm, D., Lu, H., Jing, W., Jiang, S., Forssmann, W., Kirchhoff, F.
Deposit date:2007-02-01
Release date:2007-05-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Discovery and Optimization of a Natural HIV-1 Entry Inhibitor Targeting the gp41 Fusion Peptide.
Cell(Cambridge,Mass.), 129, 2007
2KUZ
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2-AMINOPURINE INCORPORATION PERTURBS THE DYNAMICS AND STRUCTURE OF DNA
Descriptor:DNA (5'-D(*GP*CP*TP*GP*CP*AP*AP*AP*CP*GP*TP*CP*G)-3'), DNA (5'-D(*CP*GP*AP*CP*GP*TP*TP*TP*GP*CP*AP*GP*C)-3')
Authors:Dallmann, A., Dehmel, L., Peters, T., Muegge, C., Griesinger, C.P., Tuma, J., Ernsting, N.P.
Deposit date:2010-03-03
Release date:2010-07-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:2-aminopurine incorporation perturbs the dynamics and structure of DNA.
Angew.Chem.Int.Ed.Engl., 49, 2010
2KV0
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2-AMINOPURINE INCORPORATION PERTURBS THE DYNAMICS AND STRUCTURE OF DNA
Descriptor:DNA (5'-D(*GP*CP*TP*GP*CP*AP*(2PR)P*AP*CP*GP*TP*CP*G)-3'), DNA (5'-D(*CP*GP*AP*CP*GP*TP*TP*TP*GP*CP*AP*GP*C)-3')
Authors:Dallmann, A., Dehmel, L., Peters, T., Muegge, C., Griesinger, C.P., Tuma, J., Ernsting, N.P.
Deposit date:2010-03-03
Release date:2011-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:2-Aminopurine incorporation perturbs the dynamics and structure of DNA.
Angew.Chem.Int.Ed.Engl., 49, 2010
4MJ0
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BK POLYOMAVIRUS VP1 PENTAMER IN COMPLEX WITH GD3 OLIGOSACCHARIDE
Descriptor:VP1 capsid protein, O-SIALIC ACID, BETA-D-GLUCOSE, ...
Authors:Neu, U., Stroh, L.J., Stehle, T.
Deposit date:2013-09-03
Release date:2013-11-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A Structure-Guided Mutation in the Major Capsid Protein Retargets BK Polyomavirus.
Plos Pathog., 9, 2013
4MJ1
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UNLIGANDED BK POLYOMAVIRUS VP1 PENTAMER
Descriptor:VP1 capsid protein, GLYCEROL, CHLORIDE ION
Authors:Neu, U., Stroh, L.J., Stehle, T.
Deposit date:2013-09-03
Release date:2013-11-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Structure-Guided Mutation in the Major Capsid Protein Retargets BK Polyomavirus.
Plos Pathog., 9, 2013
4FMG
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MERKEL CELL POLYOMAVIRUS VP1 UNASSEMBLED PENTAMER
Descriptor:VP1, GLYCEROL, CHLORIDE ION
Authors:Neu, U., Hengel, H., Stehle, T.
Deposit date:2012-06-17
Release date:2012-09-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection.
Plos Pathog., 8, 2012
4FMH
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MERKEL CELL POLYOMAVIRUS VP1 IN COMPLEX WITH DISIALYLLACTOSE
Descriptor:VP1, GLYCEROL, CHLORIDE ION, ...
Authors:Neu, U., Hengel, H., Stehle, T.
Deposit date:2012-06-17
Release date:2012-09-05
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection.
Plos Pathog., 8, 2012
4FMI
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MERKEL CELL POLYOMAVIRUS VP1 IN COMPLEX WITH 3'-SIALYLLACTOSAMINE
Descriptor:VP1, O-SIALIC ACID, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Neu, U., Hengel, H., Stehle, T.
Deposit date:2012-06-17
Release date:2012-09-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection.
Plos Pathog., 8, 2012
4FMJ
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MERKEL CELL POLYOMAVIRUS VP1 IN COMPLEX WITH GD1A OLIGOSACCHARIDE
Descriptor:VP1, GLYCEROL, CHLORIDE ION, ...
Authors:Neu, U., Hengel, H., Stehle, T.
Deposit date:2012-06-17
Release date:2012-09-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection.
Plos Pathog., 8, 2012
6GY9
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FUCOSE-FUNCTIONALIZED PRECISION GLYCOMACROMOLECULES TARGETING HUMAN NOROVIRUS CAPSID PROTEIN
Descriptor:Capsid protein, (2~{S},3~{S},4~{R},5~{S},6~{R})-2-methyl-6-[2-(1,2,3-triazol-1-yl)ethoxy]oxane-3,4,5-triol, 1,2-ETHANEDIOL
Authors:Ruoff, K., Kilic, T., Hansman, G.S.
Deposit date:2018-06-28
Release date:2018-08-22
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Fucose-Functionalized Precision Glycomacromolecules Targeting Human Norovirus Capsid Protein.
Biomacromolecules, 19, 2018
6H9V
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CRYSTAL STRUCTURE OF DEAMINATED P DOMAIN FROM NOROVIRUS STRAIN SAGA GII-4 IN COMPLEX WITH FUC
Descriptor:VP1, ALPHA-L-METHYL-FUCOSE, MAGNESIUM ION
Authors:Meyer, P.H.O., Blaum, B.S.
Deposit date:2018-08-06
Release date:2019-04-03
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:A post-translational modification of human Norovirus capsid protein attenuates glycan binding.
Nat Commun, 10, 2019
3U0X
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CRYSTAL STRUCTURE OF THE B-SPECIFIC-1,3-GALACTOSYLTRANSFERASE (GTB) IN COMPLEX WITH COMPOUND 382
Descriptor:Histo-blood group ABO system transferase, 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine, CHLORIDE ION, ...
Authors:Palcic, M.M., Jorgensen, R.
Deposit date:2011-09-29
Release date:2012-10-24
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A novel compound from a molecular fragment library screen inhibits glycosyltransferases by displacing the metal ion and interfering with substrate binding
To be Published
3U0Y
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CRYSTAL STRUCTURE OF THE FUCOSYLGALACTOSIDE ALPHA N-ACETYLGALACTOSAMINYLTRANSFERASE (GTA, CISAB MUTANT L266G, G268A) IN COMPLEX WITH COMPOUND 382 AND UDP
Descriptor:Histo-blood group ABO system transferase, 1-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine, URIDINE-5'-DIPHOSPHATE, ...
Authors:Palcic, M.M., Jorgensen, R.
Deposit date:2011-09-29
Release date:2012-10-24
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A novel compound from a molecular fragment library screen inhibits glycosyltransferases by displacing the metal ion and interfering with substrate binding
To be Published
5TJK
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CRYSTAL STRUCTURE OF GTA + A TRISACCHARIDE (NATIVE)
Descriptor:Histo-blood group ABO system transferase, GLYCEROL, alpha-L-Fucp-(1->2)[alpha-D-GalNAcp-(1->3)]-beta-D-Galp-O(CH2)7CH3
Authors:Legg, M.S.G., Gagnon, S.M.L., Evans, S.V.
Deposit date:2016-10-04
Release date:2017-06-14
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:High-resolution crystal structures and STD NMR mapping of human ABO(H) blood group glycosyltransferases in complex with trisaccharide reaction products suggest a molecular basis for product release.
Glycobiology, 27, 2017
5TJL
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CRYSTAL STRUCTURE OF GTA + A TRISACCHARIDE (MERCURY DERIVATIVE)
Descriptor:Histo-blood group ABO system transferase, MERCURY (II) ION, alpha-L-Fucp-(1->2)[alpha-D-GalNAcp-(1->3)]-beta-D-Galp-O(CH2)7CH3
Authors:Legg, M.S.G., Gagnon, S.M.L., Evans, S.V.
Deposit date:2016-10-04
Release date:2017-06-14
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:High-resolution crystal structures and STD NMR mapping of human ABO(H) blood group glycosyltransferases in complex with trisaccharide reaction products suggest a molecular basis for product release.
Glycobiology, 27, 2017
5TJN
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CRYSTAL STRUCTURE OF GTB + B TRISACCHARIDE (NATIVE)
Descriptor:Histo-blood group ABO system transferase, alpha-L-Fucp-(1->2)[alpha-D-Galp-(1->3)]-beta-D-Galp-O(CH2)7CH3, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Legg, M.S.G., Gagnon, S.M.L., Evans, S.V.
Deposit date:2016-10-04
Release date:2017-06-14
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:High-resolution crystal structures and STD NMR mapping of human ABO(H) blood group glycosyltransferases in complex with trisaccharide reaction products suggest a molecular basis for product release.
Glycobiology, 27, 2017
5TJO
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CRYSTAL STRUCTURE OF GTB + B TRISACCHARIDE (MERCURY DERIVATIVE)
Descriptor:Histo-blood group ABO system transferase, MERCURY (II) ION, alpha-L-Fucp-(1->2)[alpha-D-Galp-(1->3)]-beta-D-Galp-O(CH2)7CH3
Authors:Legg, M.S.G., Gagnon, S.M.L., Evans, S.V.
Deposit date:2016-10-04
Release date:2017-06-14
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:High-resolution crystal structures and STD NMR mapping of human ABO(H) blood group glycosyltransferases in complex with trisaccharide reaction products suggest a molecular basis for product release.
Glycobiology, 27, 2017
2L6S
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EFFICACY OF AN HIV-1 ENTRY INHIBITOR TARGETING THE GP41 FUSION PEPTIDE
Descriptor:VIR-576
Authors:Forssmann, W., The, Y., Stoll, M., Adermann, K., Albrecht, U., Barlos, K., Busmann, A., Canales-Mayordomo, A., Gimenez-Gallego, G., Hirsch, J., Jimenez-Barbero, J., Meyer-Olson, D., Muench, J., Perez-Castells, J., Standker, L., Kirchhoff, F., Schmidt, R.E.
Deposit date:2010-11-24
Release date:2011-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide.
Sci Transl Med, 2, 2010
2L6T
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EFFICACY OF AN HIV-1 ENTRY INHIBITOR TARGETING THE GP41 FUSION PEPTIDE
Descriptor:VIR-576
Authors:Forssmann, W., The, Y., Stoll, M., Adermann, K., Albrecht, U., Barlos, K., Busmann, A., Can les-Mayordomo, A., Gimenez-Gallego, G., Hirsch, J., Jimenez-Barbero, J., Meyer-Olson, D., Muench, J., Perez-Castells, J., Staendker, L., Kirchhoff, F., Schmidt, R.E.
Deposit date:2010-11-24
Release date:2011-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Short-term monotherapy in HIV-infected patients with a virus entry inhibitor against the gp41 fusion peptide.
Sci Transl Med, 2, 2010