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5UZ7
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VOLTA PHASE PLATE CRYO-ELECTRON MICROSCOPY STRUCTURE OF A CALCITONIN RECEPTOR-HETEROTRIMERIC GS PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liang, Y.L., Khoshouei, M., Radjainia, M., Zhang, Y., Glukhova, A., Tarrasch, J., Thal, D.M., Furness, S.G.B., Christopoulos, G., Coudrat, T., Danev, R., Baumeister, W., Miller, L.J., Christopoulos, A., Kobilka, B.K., Wootten, D., Skiniotis, G., Sexton, P.M.
Deposit date:2017-02-24
Release date:2017-05-03
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.
Nature, 546, 2017
6B3J
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3.3 ANGSTROM PHASE-PLATE CRYO-EM STRUCTURE OF A BIASED AGONIST-BOUND HUMAN GLP-1 RECEPTOR-GS COMPLEX
Descriptor:Glucagon-like peptide 1 receptor, Exendin-P5, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Liang, Y.L., Khoshouei, M., Glukhova, A., Furness, S.G.B., Koole, C., Zhao, P., Clydesdale, L., Thal, D.M., Radjainia, M., Danev, R., Baumeister, W., Wang, M.W., Miller, L.J., Christopoulos, A., Sexton, P.M., Wootten, D.
Deposit date:2017-09-22
Release date:2018-02-21
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.
Nature, 555, 2018
6E3Y
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CRYO-EM STRUCTURE OF THE ACTIVE, GS-PROTEIN COMPLEXED, HUMAN CGRP RECEPTOR
Descriptor:Calcitonin gene-related peptide 1, Nanobody 35, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Liang, Y.L., Khoshouei, M., Deganutti, G., Glukhova, A., Koole, C., Peat, T.S., Radjainia, M., Plitzko, J.M., Baumeister, W., Miller, L.J., Hay, D.L., Christopoulos, A., Reynolds, C.A., Wootten, D., Sexton, P.M.
Deposit date:2018-07-16
Release date:2018-09-19
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.
Nature, 561, 2018
6NIY
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A HIGH-RESOLUTION CRYO-ELECTRON MICROSCOPY STRUCTURE OF A CALCITONIN RECEPTOR-HETEROTRIMERIC GS PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Nanobody35, Calcitonin receptor, ...
Authors:dal Maso, E., Glukhova, A., Zhu, Y., Garcia-Nafria, J., Tate, C.G., Atanasio, S., Reynolds, C.A., Ramirez-Aportela, E., Carazo, J.-M., Hick, C.A., Furness, S.G.B., Hay, D.L., Liang, Y.-L., Miller, L.J., Christopoulos, A., Wang, M.-W., Wootten, D., Sexton, P.M.
Deposit date:2019-01-02
Release date:2019-01-23
Last modified:2020-04-08
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:The Molecular Control of Calcitonin Receptor Signaling.
Acs Pharmacol Transl Sci, 2, 2019
6X18
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GLP-1 PEPTIDE HORMONE BOUND TO GLUCAGON-LIKE PEPTIDE-1 (GLP-1) RECEPTOR
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J., Zhang, X., Danev, R.
Deposit date:2020-05-18
Release date:2020-09-09
Last modified:2020-10-21
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 2020
6X19
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NON PEPTIDE AGONIST CHU-128, BOUND TO GLUCAGON-LIKE PEPTIDE-1 (GLP-1) RECEPTOR
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J., Zhang, X., Danev, R.
Deposit date:2020-05-18
Release date:2020-09-09
Last modified:2020-10-21
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 2020
6X1A
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NON PEPTIDE AGONIST PF-06882961, BOUND TO GLUCAGON-LIKE PEPTIDE-1 (GLP-1) RECEPTOR
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J., Zhang, X., Danev, R.
Deposit date:2020-05-18
Release date:2020-09-09
Last modified:2020-10-21
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.
Mol.Cell, 2020
3L2J
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DIMERIC STRUCTURE OF THE LIGAND-FREE EXTRACELLULAR DOMAIN OF THE HUMAN PARATHYROID HORMONE RECEPTOR (PTH1R)
Descriptor:Fusion protein of Maltose-binding periplasmic protein and Parathyroid hormone/parathyroid hormone-related peptide receptor, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Pioszak, A.A., Xu, H.E.
Deposit date:2009-12-15
Release date:2010-02-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation.
J.Biol.Chem., 285, 2010
4MY2
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CRYSTAL STRUCTURE OF NORRIN IN FUSION WITH MALTOSE BINDING PROTEIN
Descriptor:Maltose-binding periplasmic protein, Norrin fusion protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Ke, J., Jurecky, C., Chen, C., Gu, X., Parker, N., Williams, B.O., Melcher, K., Xu, H.E.
Deposit date:2013-09-27
Release date:2013-11-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.
Genes Dev., 27, 2013
5UWG
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THE CRYSTAL STRUCTURE OF FZ4-CRD IN COMPLEX WITH PALMITOLEIC ACID
Descriptor:Frizzled-4, PALMITOLEIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Ke, J., DeBruine, Z.J., Gu, X., Brunzelle, J.S., Xu, H.E., Melcher, K.
Deposit date:2017-02-21
Release date:2017-06-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.
Genes Dev., 31, 2017
6BD4
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CRYSTAL STRUCTURE OF HUMAN APO-FRIZZLED4 RECEPTOR
Descriptor:Frizzled-4/Rubredoxin chimeric protein, ZINC ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Yang, S., Wu, Y., Pu, M., Chen, Y., Dong, S., Guo, Y., Han, G.Y., Stevens, R.C., Zhao, S., Xu, F.
Deposit date:2017-10-21
Release date:2018-08-22
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
6ORV
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NON-PEPTIDE AGONIST (TT-OAD2) BOUND TO THE GLUCAGON-LIKE PEPTIDE-1 (GLP-1) RECEPTOR
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J., Liang, Y.L., Danev, R.
Deposit date:2019-05-01
Release date:2020-01-08
Last modified:2020-01-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Activation of the GLP-1 receptor by a non-peptidic agonist.
Nature, 577, 2020
6UUN
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CRYOEM STRUCTURE OF THE ACTIVE ADRENOMEDULLIN 1 RECEPTOR G PROTEIN COMPLEX WITH ADRENOMEDULLIN PEPTIDE
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Receptor activity-modifying protein 2, ...
Authors:Belousoff, M.J., Liang, Y.L., Sexton, P., Danev, R.
Deposit date:2019-10-30
Release date:2020-03-25
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Acs Pharmacol Transl Sci, 3, 2020
6UUS
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CRYOEM STRUCTURE OF THE ACTIVE ADRENOMEDULLIN 2 RECEPTOR G PROTEIN COMPLEX WITH ADRENOMEDULLIN PEPTIDE
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J., Liang, Y.L., Sexton, P., Danev, R.
Deposit date:2019-10-31
Release date:2020-04-01
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Acs Pharmacol Transl Sci, 3, 2020
6UVA
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CRYOEM STRUCTURE OF THE ACTIVE ADRENOMEDULLIN 2 RECEPTOR G PROTEIN COMPLEX WITH ADRENOMEDULLIN 2 PEPTIDE
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J., Liang, Y.L., Sexton, P., Danev, R.
Deposit date:2019-11-01
Release date:2020-04-01
Last modified:2020-04-29
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
Acs Pharmacol Transl Sci, 3, 2020
6WI9
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HUMAN SECRETIN RECEPTOR GS COMPLEX
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Belousoff, M.J., Khoshouei, M.
Deposit date:2020-04-09
Release date:2020-08-12
Last modified:2020-09-02
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure and dynamics of the active Gs-coupled human secretin receptor.
Nat Commun, 11, 2020
6WZG
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HUMAN SECRETIN RECEPTOR GS COMPLEX
Descriptor:Secretin, Secretin receptor, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Piper, S.J., Belousoff, M.J., Danev, R.
Deposit date:2020-05-13
Release date:2020-08-12
Last modified:2020-09-02
Method:ELECTRON MICROSCOPY (2.3 Å)
Cite:Structure and dynamics of the active Gs-coupled human secretin receptor.
Nat Commun, 11, 2020
170172
PDB entries from 2020-10-21