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3JCS
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2.8 ANGSTROM CRYO-EM STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM THE EUKARYOTIC PARASITE LEISHMANIA
Descriptor:26S alpha ribosomal RNA, 26S delta ribosomal RNA, 26S gamma ribosomal RNA, ...
Authors:Shalev-Benami, M., Zhang, Y., Matzov, D., Halfon, Y., Zackay, A., Rozenberg, H., Zimmerman, E., Bashan, A., Jaffe, C.L., Yonath, A., Skiniotis, G.
Deposit date:2016-01-21
Release date:2016-07-20
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
Cell Rep, 16, 2016
4ZC7
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PAROMOMYCIN BOUND TO A LEISHMANIAL RIBOSOMAL A-SITE
Descriptor:RNA duplex, PAROMOMYCIN
Authors:Shalev, M., Rozenberg, H., Jaffe, C.L., Adir, N., Baasov, T.
Deposit date:2015-04-15
Release date:2015-08-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.041 Å)
Cite:Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics.
Nucleic Acids Res., 43, 2015
6AZ1
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CRYO-EM STRUCTURE OF THE SMALL SUBUNIT OF LEISHMANIA RIBOSOME BOUND TO PAROMOMYCIN
Descriptor:Ribosomal protein s1e, ribosomal protein S2, ribosomal protein S3, ...
Authors:Shalev-Benami, M., Zhang, Y., Rozenberg, H., Matzov, D., Zimmerman, E., Bashan, A., Jaffe, C.L., Yonath, A., Skiniotis, G.
Deposit date:2017-09-09
Release date:2017-12-06
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Nat Commun, 8, 2017
6AZ3
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CRYO-EM STRUCTURE OF OF THE LARGE SUBUNIT OF LEISHMANIA RIBOSOME BOUND TO PAROMOMYCIN
Descriptor:ribosomal protein uL2, ribosomal protein uL3, ribosomal protein uL4, ...
Authors:Shalev-Benami, M., Zhang, Y., Rozenberg, H., Nobe, Y., Taoka, M., Matzov, D., Zimmerman, E., Bashan, A., Isobe, T., Jaffe, C.L., Yonath, A., Skiniotis, G.
Deposit date:2017-09-09
Release date:2017-12-06
Last modified:2017-12-13
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Nat Commun, 8, 2017
4K31
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CRYSTAL STRUCTURE OF APRAMYCIN BOUND TO THE LEISHMANIAL RRNA A-SITE
Descriptor:RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*UP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3'), APRAMYCIN
Authors:Shalev, M., Kondo, J., Adir, N., Baasov, T.
Deposit date:2013-04-10
Release date:2013-07-31
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (1.415 Å)
Cite:Identification of the molecular attributes required for aminoglycoside activity against Leishmania.
Proc.Natl.Acad.Sci.USA, 110, 2013
4K32
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CRYSTAL STRUCTURE OF GENETICIN BOUND TO THE LEISHMANIAL RRNA A-SITE
Descriptor:RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*GP*UP*UP*CP*CP*GP*GP*AP*AP*AP*AP*GP*UP*CP*GP*C)-3'), GENETICIN
Authors:Shalev, M., Kondo, J., Adir, N., Baasov, T.
Deposit date:2013-04-10
Release date:2013-07-31
Last modified:2013-09-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Identification of the molecular attributes required for aminoglycoside activity against Leishmania.
Proc.Natl.Acad.Sci.USA, 110, 2013