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4IBT
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R273H AND SECOND-SITE SUPPRESSOR MUTATION T284R
Descriptor:Cellular tumor antigen p53, ZINC ION
Authors:Diskin-Posner, Y., Eldar, A., Rozenberg, H., Shakked, Z.
Deposit date:2012-12-09
Release date:2013-08-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41, 2013
4IBQ
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R273C
Descriptor:Cellular tumor antigen p53, ZINC ION, ACETATE ION, ...
Authors:Rozenberg, H., Eldar, A., Diskin-Posner, Y., Shakked, Z.
Deposit date:2012-12-09
Release date:2013-08-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41, 2013
4IBS
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R273H (FORM I)
Descriptor:Cellular tumor antigen p53, ZINC ION, 1,2-ETHANEDIOL
Authors:Rozenberg, H., Eldar, A., Diskin-Posner, Y., Shakked, Z.
Deposit date:2012-12-09
Release date:2013-08-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41, 2013
4IBU
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R273C AND SECOND-SITE SUPPRESSOR MUTATION T284R IN SEQUENCE-SPECIFIC COMPLEX WITH DNA
Descriptor:Cellular tumor antigen p53, DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3'), ZINC ION, ...
Authors:Eldar, A., Rozenberg, H., Diskin-Posner, Y., Shakked, Z.
Deposit date:2012-12-09
Release date:2013-08-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41, 2013
4IBV
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R273C AND SECOND-SITE SUPPRESSOR MUTATION S240R IN SEQUENCE-SPECIFIC COMPLEX WITH DNA
Descriptor:Cellular tumor antigen p53, DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3'), 1,2-ETHANEDIOL, ...
Authors:Eldar, A., Rozenberg, H., Diskin-Posner, Y., Shakked, Z.
Deposit date:2012-12-09
Release date:2013-08-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41, 2013
4IBW
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R273H AND SECOND-SITE SUPPRESSOR MUTATION T284R IN SEQUENCE-SPECIFIC COMPLEX WITH DNA
Descriptor:Cellular tumor antigen p53, DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3'), ZINC ION, ...
Authors:Eldar, A., Rozenberg, H., Diskin-Posner, Y., Shakked, Z.
Deposit date:2012-12-09
Release date:2013-08-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.791 Å)
Cite:Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41, 2013
4IBY
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R273H AND SECOND-SITE SUPPRESSOR MUTATION S240R
Descriptor:Cellular tumor antigen p53, ZINC ION, 1,2-ETHANEDIOL
Authors:Eldar, A., Rozenberg, H., Diskin-Posner, Y., Shakked, Z.
Deposit date:2012-12-09
Release date:2013-08-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41, 2013
4IBZ
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R273C AND SECOND-SITE SUPPRESSOR MUTATION T284R
Descriptor:Cellular tumor antigen p53, ZINC ION, 1,2-ETHANEDIOL, ...
Authors:Eldar, A., Rozenberg, H., Diskin-Posner, Y., Shakked, Z.
Deposit date:2012-12-09
Release date:2013-08-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41, 2013
4IJT
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R273H (FORM II)
Descriptor:Cellular tumor antigen p53, ZINC ION, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ...
Authors:Rozenberg, H., Eldar, A., Diskin-Posner, Y., Shakked, Z.
Deposit date:2012-12-23
Release date:2013-08-14
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.
Nucleic Acids Res., 41, 2013
5JVG
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THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS IN COMPLEX WITH AVILAMYCIN
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Krupkin, M., Wekselman, I., Matzov, D., Eyal, Z., Diskin Posner, Y., Rozenberg, H., Zimmerman, E., Bashan, A., Yonath, A.
Deposit date:2016-05-11
Release date:2016-11-09
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (3.428 Å)
Cite:Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding.
Proc.Natl.Acad.Sci.USA, 113, 2016
3D05
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R249S (II)
Descriptor:Cellular tumor antigen p53, ZINC ION
Authors:Suad, O., Rozenberg, H., Shimon, L.J.W., Frolow, F., Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
3D06
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R249S (I)
Descriptor:Cellular tumor antigen p53, ZINC ION
Authors:Rozenberg, H., Suad, O., Shimon, L.J.W., Frolow, F., Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
3D07
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R249S (III)
Descriptor:Cellular tumor antigen p53, ZINC ION
Authors:Suad, O., Rozenberg, H., Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
3D08
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R249S AND SECOND-SITE SUPPRESSOR MUTATION H168R
Descriptor:Cellular tumor antigen p53, ZINC ION
Authors:Suad, O., Rozenberg, H., Shimon, L.J.W., Frolow, F., Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
3D09
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R249S AND SECOND-SITE SUPPRESSOR MUTATIONS H168R AND T123A
Descriptor:Cellular tumor antigen p53, ZINC ION
Authors:Rozenberg, H., Suad, O., Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
3D0A
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HUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R249S AND SECOND SITE SUPPRESSOR MUTATION H168R IN SEQUENCE-SPECIFIC COMPLEX WITH DNA
Descriptor:DNA (5'-D(*DCP*DGP*DGP*DGP*DCP*DAP*DTP*DGP*DCP*DCP*DCP*DG)-3'), Cellular tumor antigen p53, ZINC ION
Authors:Suad, O., Rozenberg, H., Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
5JVH
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THE CRYSTAL STRUCTURE LARGE RIBOSOMAL SUBUNIT (50S) OF DEINOCOCCUS RADIODURANS IN COMPLEX WITH EVERNIMICIN
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Yonath, A.
Deposit date:2016-05-11
Release date:2016-11-09
Method:X-RAY DIFFRACTION (3.58 Å)
Cite:Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding.
Proc.Natl.Acad.Sci.USA, 113, 2016
5MF7
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NEW INSIGHTS INTO THE ROLE OF DNA SHAPE ON ITS RECOGNITION BY P53 PROTEINS (COMPLEX P53DBD-GADD45)
Descriptor:Cellular tumor antigen p53, DNA, ZINC ION, ...
Authors:Rozenberg, H., Diskin-Posner, Y., Golovenko, D., Shakked, Z.
Deposit date:2016-11-17
Release date:2018-05-30
Last modified:2019-01-02
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018