Author results

1FIM
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MACROPHAGE MIGRATION INHIBITORY FACTOR
Descriptor:MACROPHAGE MIGRATION INHIBITORY FACTOR
Authors:Suzuki, M., Sugimoto, H., Nakagawa, A., Tanaka, I.
Deposit date:1996-01-31
Release date:1996-07-11
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of the macrophage migration inhibitory factor from rat liver.
Nat.Struct.Biol., 3, 1996
1PC2
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SOLUTION STRUCTURE OF HUMAN MITOCHONDRIA FISSION PROTEIN FIS1
Descriptor:mitochondria fission protein
Authors:Suzuki, M., Youle, R.J., Tjandra, N.
Deposit date:2003-05-15
Release date:2003-12-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Solution Structure of Human Mitochondria Fission Protein Fis1 Reveals a Novel TPR-like Helix Bundle
J.Mol.Biol., 334, 2003
1UIZ
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CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR FROM XENOPUS LAEVIS.
Descriptor:Macrophage Migration Inhibitory Factor
Authors:Suzuki, M., Takamura, Y., Maeno, M., Tochinai, S., Iyaguchi, D., Tanaka, I., Nishihira, J., Ishibashi, T.
Deposit date:2003-07-24
Release date:2004-05-25
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Xenopus laevis Macrophage Migration Inhibitory Factor Is Essential for Axis Formation and Neural Development.
J.Biol.Chem., 279, 2004
3VOT
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CRYSTAL STRUCTURE OF L-AMINO ACID LIGASE FROM BACILLUS LICHENIFORMIS
Descriptor:L-amino acid ligase, BL00235, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Suzuki, M., Takahashi, Y., Noguchi, A., Arai, T., Yagasaki, M., Kino, K., Saito, J.
Deposit date:2012-02-08
Release date:2012-11-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of L-amino-acid ligase from Bacillus licheniformis
Acta Crystallogr.,Sect.D, 68, 2012
5HWA
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CRYSTAL STRUCTURE OF MH-K1 CHITOSANASE IN SUBSTRATE-BOUND FORM
Descriptor:Chitosanase, D-GLUCOSAMINE, CACODYLATE ION, ...
Authors:Suzuki, M., Saito, A., Ando, A., Miki, K., Saito, J.
Deposit date:2016-01-29
Release date:2017-02-08
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Understanding for the catalytic mechanism based on the substrate-bound structure of GH-46 chitosanase from Bacillus circulans MH-K1
to be published
1F16
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SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
Descriptor:PROTEIN (APOPTOSIS REGULATOR BAX, MEMBRANE ISOFORM ALPHA)
Authors:Suzuki, M., Youle, R.J., Tjandra, N.
Deposit date:2000-05-18
Release date:2000-11-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of Bax: coregulation of dimer formation and intracellular localization.
Cell(Cambridge,Mass.), 103, 2000
1Y8M
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SOLUTION STRUCTURE OF YEAST MITOCHONDRIA FISSION PROTEIN FIS1
Descriptor:Fis1
Authors:Suzuki, M., Youle, R.J., Tjandra, N.
Deposit date:2004-12-13
Release date:2005-04-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.
J.Biol.Chem., 280, 2005
2JZ7
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SOLUTION NMR STRUCTURE OF SELENIUM-BINDING PROTEIN FROM METHANOCOCCUS VANNIELII
Descriptor:Selenium binding protein
Authors:Suzuki, M., Stadtman, T.C., Tjandra, N.
Deposit date:2007-12-28
Release date:2008-07-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR Structure of Selenium-binding Protein from Methanococcus vannielii.
J.Biol.Chem., 283, 2008
2D1J
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FACTOR XA IN COMPLEX WITH THE INHIBITOR 2-[[4-[(5-CHLOROINDOL-2-YL)SULFONYL]PIPERAZIN-1-YL] CARBONYL]THIENO[3,2-B]PYRIDINE N-OXIDE
Descriptor:Coagulation factor X, heavy chain, light chain, ...
Authors:Suzuki, M.
Deposit date:2005-08-24
Release date:2006-08-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites.
Bioorg.Med.Chem., 13, 2005
1WU1
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FACTOR XA IN COMPLEX WITH THE INHIBITOR 4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL) PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE
Descriptor:Coagulation factor X, heavy chain, light chain, ...
Authors:Suzuki, M.
Deposit date:2004-11-29
Release date:2005-11-29
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites
Bioorg.Med.Chem., 13, 2005
6IO0
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HUMAN IDH1 R132C MUTANT COMPLEXED WITH COMPOUND A.
Descriptor:Isocitrate dehydrogenase [NADP] cytoplasmic, (2E)-3-{3-[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole-4-carbonyl]-1-methyl-1H-indol-7-yl}prop-2-enoic acid, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Suzuki, M., Baba, D., Hanzawa, H.
Deposit date:2018-10-29
Release date:2019-10-30
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A potent blood-brain barrier-permeable mutant IDH1 inhibitor suppresses the growth of glioblastoma with IDH1 mutation in a patient-derived orthotopic xenograft model.
Mol.Cancer Ther., 2019
6KG2
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HUMAN MTHFD2 IN COMPLEX WITH COMPOUND 18
Descriptor:Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, N-[2-chloranyl-4-[[7-methyl-8-(4-methylpiperazin-1-yl)-5-oxidanylidene-2,4-dihydro-1H-chromeno[3,4-c]pyridin-3-yl]carbonyl]phenyl]methanesulfonamide, ...
Authors:Suzuki, M., Matsui, Y., Ota, M., Kawai, J.
Deposit date:2019-07-10
Release date:2019-11-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with In Vivo Anti-Tumor Activity.
J.Med.Chem., 2019
3Q2Z
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HUMAN SQUALENE SYNTHASE IN COMPLEX WITH N-[(3R,5S)-7-CHLORO-5-(2,3-DIMETHOXYPHENYL)-1-NEOPENTYL-2-OXO-1,2,3,5-TETRAHYDRO-4,1-BENZOXAZEPINE-3-ACETYL]-L-ASPARTIC ACID
Descriptor:Squalene synthase, PHOSPHATE ION, N-{[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl}-L-aspartic acid
Authors:Suzuki, M., Shimizu, H., Katakura, S., Yamazaki, K., Higashihashi, N., Ichikawa, M., Yokomizo, A., Itoh, M., Sugita, K., Usui, H.
Deposit date:2010-12-21
Release date:2011-12-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors
Bioorg.Med.Chem., 19, 2011
3Q30
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HUMAN SQUALENE SYNTHASE IN COMPLEX WITH (2R,3R)-2-CARBOXYMETHOXY-3-[5-(2-NAPHTHALENYL)PENTYL]AMINOCARBONYL-3-[5-(2-NAPHTHALENYL)PENTYLOXY]PROPIONIC ACID
Descriptor:Squalene synthase, MAGNESIUM ION, (2R,3R)-2-(carboxymethoxy)-4-{[5-(naphthalen-2-yl)pentyl]amino}-3-{[5-(naphthalen-2-yl)pentyl]oxy}-4-oxobutanoic acid, ...
Authors:Suzuki, M., Shimizu, H., Katakura, S., Yamazaki, K., Higashihashi, N., Ichikawa, M., Yokomizo, A., Itoh, M., Sugita, K., Usui, H.
Deposit date:2010-12-21
Release date:2011-12-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors
Bioorg.Med.Chem., 19, 2011
3V66
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HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-CHLORO-6-(2,3-DIMETHOXYPHENYL)-4H,6H-PYRROLO[1,2-A][4,1]BENZOXAZEPIN-4-YL]ACETYL}-4-PIPERIDINYL)ACETIC ACID
Descriptor:Squalene synthase, PHOSPHATE ION, (1-{[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}piperidin-4-yl)acetic acid
Authors:Suzuki, M., Ohtsuka, M., Ohki, H., Haginoya, N., Itoh, M., Sugita, K., Usui, H., Ichikawa, M., Higashihashi, N.
Deposit date:2011-12-18
Release date:2012-12-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of novel tricyclic compounds as squalene synthase inhibitors
Bioorg.Med.Chem., 20, 2012
2EI8
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FACTOR XA IN COMPLEX WITH THE INHIBITOR (1S,2R,4S)-N1-[(5-CHLOROINDOL-2-YL)CARBONYL]-4-(N,N-DIMETHYLCARBAMOYL)-N2-[(5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDIN-2-YL)CARBONYL]-1,2-CYCLOHEXANEDIAMINE
Descriptor:Coagulation factor X, heavy chain, light chain, ...
Authors:Suzuki, M.
Deposit date:2007-03-12
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery of N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A Novel, Potent and Orally Active Direct Inhibitor of Factor Xa
To be Published
3H7G
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APO-FR WITH AU IONS
Descriptor:Ferritin light chain, GOLD 3+ ION, CADMIUM ION, ...
Authors:Abe, M., Ueno, T., Abe, S., Suzuki, M., Goto, T., Toda, Y., Akita, T., Yamada, Y., Watanabe, Y.
Deposit date:2009-04-27
Release date:2009-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Preparation and catalytic reaction of Au/Pd bimetallic nanoparticles in apo-ferritin
Chem.Commun.(Camb.), 32, 2009
3Q3K
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FACTOR XA IN COMPLEX WITH A PHENYLENEDIAMINE DERIVATIVE
Descriptor:Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M., Imai, E.
Deposit date:2010-12-22
Release date:2011-12-28
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3TK5
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FACTOR XA IN COMPLEX WITH D102-4380
Descriptor:Factor X heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M., Mochizuki, A., Nagata, T., Takano, H., Kanno, H., Kishida, M., Ohta, T.
Deposit date:2011-08-25
Release date:2012-08-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Zwitter ionic potent durable orally active Factor Xa inhibitor.
To be Published
3TK6
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FACTOR XA IN COMPLEX WITH D46-5241
Descriptor:Factor X heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M., Mochizuki, A., Nagata, T., Takano, H., Kanno, H., Kishida, M., Ohta, T.
Deposit date:2011-08-25
Release date:2012-08-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Zwitter ionic potent durable orally active Factor Xa inhibitor.
To be Published
5ZYG
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND B5
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[3-~{tert}-butyl-5-(2-pyridin-2-ylethyl)phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYH
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E5
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[3-~{tert}-butyl-5-[(1~{R},2~{S})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYI
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E16
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-pentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYJ
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E16A
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-pentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol, GLYCEROL
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYK
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E25
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-cyclopentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019