Author results

6BX3
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STRUCTURE OF HISTONE H3K4 METHYLTRANSFERASE
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-4 specific, COMPASS component BRE2, ...
Authors:Skiniotis, G., Qu, Q.H.
Deposit date:2017-12-16
Release date:2018-09-05
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.
Cell, 174, 2018
5UZ7
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VOLTA PHASE PLATE CRYO-ELECTRON MICROSCOPY STRUCTURE OF A CALCITONIN RECEPTOR-HETEROTRIMERIC GS PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liang, Y.L., Khoshouei, M., Radjainia, M., Zhang, Y., Glukhova, A., Tarrasch, J., Thal, D.M., Furness, S.G.B., Christopoulos, G., Coudrat, T., Danev, R., Baumeister, W., Miller, L.J., Christopoulos, A., Kobilka, B.K., Wootten, D., Skiniotis, G., Sexton, P.M.
Deposit date:2017-02-24
Release date:2017-05-03
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.
Nature, 546, 2017
6WPW
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GCGR-GS SIGNALING COMPLEX BOUND TO A DESIGNED GLUCAGON DERIVATIVE
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Hilger, D., Krishna Kumar, K., Hu, H., Mathiesen, J.M., Skiniotis, G., Kobilka, B.K.
Deposit date:2020-04-28
Release date:2020-08-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into differences in G protein activation by family A and family B GPCRs.
Science, 369, 2020
2V5M
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STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY
Descriptor:DSCAM, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL
Authors:Meijers, R., Puettmann-Holgado, R., Skiniotis, G., Liu, J.-H., Walz, T., Schmucker, D., Wang, J.-H.
Deposit date:2007-07-06
Release date:2007-09-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis of Dscam Isoform Specificity
Nature, 449, 2007
2V5R
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STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY
Descriptor:DSCAM, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL
Authors:Meijers, R., Puettmann-Holgado, R., Skiniotis, G., Liu, J.-H., Walz, T., Schmucker, D., Wang, J.-H.
Deposit date:2007-07-09
Release date:2007-09-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis of Dscam Isoform Specificity
Nature, 449, 2007
2V5S
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STRUCTURAL BASIS FOR DSCAM ISOFORM SPECIFICITY
Descriptor:DSCAM, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Meijers, R., Puettmann-Holgado, R., Skiniotis, G., Liu, J.-H., Walz, T., Schmucker, D., Wang, J.-H.
Deposit date:2007-07-09
Release date:2007-09-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis of Dscam Isoform Specificity
Nature, 449, 2007
3JCS
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2.8 ANGSTROM CRYO-EM STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM THE EUKARYOTIC PARASITE LEISHMANIA
Descriptor:26S alpha ribosomal RNA, 26S delta ribosomal RNA, 26S gamma ribosomal RNA, ...
Authors:Shalev-Benami, M., Zhang, Y., Matzov, D., Halfon, Y., Zackay, A., Rozenberg, H., Zimmerman, E., Bashan, A., Jaffe, C.L., Yonath, A., Skiniotis, G.
Deposit date:2016-01-21
Release date:2016-07-20
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
Cell Rep, 16, 2016
3SN6
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CRYSTAL STRUCTURE OF THE BETA2 ADRENERGIC RECEPTOR-GS PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Rasmussen, S.G.F., DeVree, B.T., Zou, Y., Kruse, A.C., Chung, K.Y., Kobilka, T.S., Thian, F.S., Chae, P.S., Pardon, E., Calinski, D., Mathiesen, J.M., Shah, S.T.A., Lyons, J.A., Caffrey, M., Gellman, S.H., Steyaert, J., Skiniotis, G., Weis, W.I., Sunahara, R.K., Kobilka, B.K.
Deposit date:2011-06-28
Release date:2011-07-20
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the beta2 adrenergic receptor-Gs protein complex
Nature, 477, 2011
4X8N
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CRYSTAL STRUCTURE OF ASH2L SPRY DOMAIN IN COMPLEX WITH PHOSPHORYLATED RBBP5
Descriptor:Set1/Ash2 histone methyltransferase complex subunit ASH2, Retinoblastoma-binding protein 5
Authors:Zhang, P., Chaturvedi, C.P., Brunzelle, J.S., Skiniotis, G., Brand, M., Shilatifard, A., Couture, J.-F.
Deposit date:2014-12-10
Release date:2015-01-28
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.
Genes Dev., 29, 2015
4X8P
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CRYSTAL STRUCTURE OF ASH2L SPRY DOMAIN IN COMPLEX WITH RBBP5
Descriptor:Set1/Ash2 histone methyltransferase complex subunit ASH2,Set1/Ash2 histone methyltransferase complex subunit ASH2, Retinoblastoma-binding protein 5, GLYCEROL
Authors:Zhang, P., Chaturvedi, C.P., Brunzelle, J.S., Skiniotis, G., Brand, M., Shilatifard, A., Couture, J.-F.
Deposit date:2014-12-10
Release date:2015-01-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation.
Genes Dev., 29, 2015
5UQ7
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70S RIBOSOME COMPLEX WITH DNAX MRNA STEMLOOP AND E-SITE TRNA ("IN" CONFORMATION)
Descriptor:23S rRNA, 5S rRNA, 50S ribosomal protein L2, ...
Authors:Zhang, Y., Hong, S., Skiniotis, G., Dunham, C.M.
Deposit date:2017-02-07
Release date:2018-03-07
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Alternative Mode of E-Site tRNA Binding in the Presence of a Downstream mRNA Stem Loop at the Entrance Channel.
Structure, 26, 2018
5UQ8
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70S RIBOSOME COMPLEX WITH DNAX MRNA STEM-LOOP AND E-SITE TRNA ("OUT" CONFORMATION)
Descriptor:23S rRNA, 5S rRNA, 50S ribosomal protein L2, ...
Authors:Zhang, Y., Hong, S., Skiniotis, G., Dunham, C.M.
Deposit date:2017-02-07
Release date:2018-03-07
Last modified:2018-03-21
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Alternative Mode of E-Site tRNA Binding in the Presence of a Downstream mRNA Stem Loop at the Entrance Channel.
Structure, 26, 2018
5VAI
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CRYO-EM STRUCTURE OF THE ACTIVATED GLUCAGON-LIKE PEPTIDE-1 RECEPTOR IN COMPLEX WITH G PROTEIN
Descriptor:Uncharacterized protein, Glucagon-like peptide 1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Zhang, Y., Sun, B., Feng, D., Hu, H., Chu, M., Qu, Q., Tarrasch, J.T., Li, S., Kobilka, T.S., Kobilka, B.K., Skiniotis, G.
Deposit date:2017-03-27
Release date:2017-05-24
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.
Nature, 546, 2017
6AZ1
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CRYO-EM STRUCTURE OF THE SMALL SUBUNIT OF LEISHMANIA RIBOSOME BOUND TO PAROMOMYCIN
Descriptor:Ribosomal protein s1e, ribosomal protein S2, ribosomal protein S3, ...
Authors:Shalev-Benami, M., Zhang, Y., Rozenberg, H., Matzov, D., Zimmerman, E., Bashan, A., Jaffe, C.L., Yonath, A., Skiniotis, G.
Deposit date:2017-09-09
Release date:2017-12-06
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Nat Commun, 8, 2017
6AZ3
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CRYO-EM STRUCTURE OF OF THE LARGE SUBUNIT OF LEISHMANIA RIBOSOME BOUND TO PAROMOMYCIN
Descriptor:ribosomal protein uL2, ribosomal protein uL3, ribosomal protein uL4, ...
Authors:Shalev-Benami, M., Zhang, Y., Rozenberg, H., Nobe, Y., Taoka, M., Matzov, D., Zimmerman, E., Bashan, A., Isobe, T., Jaffe, C.L., Yonath, A., Skiniotis, G.
Deposit date:2017-09-09
Release date:2017-12-06
Last modified:2017-12-13
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Nat Commun, 8, 2017
6B19
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ARCHITECTURE OF HIV-1 REVERSE TRANSCRIPTASE INITIATION COMPLEX CORE
Descriptor:reverse transcriptase p66 subunit, reverse transcriptase p51 subunit, RNA genome fragment, ...
Authors:Larsen, K.P., Mathiharan, Y.K., Chen, D.H., Puglisi, J.D., Skiniotis, G., Puglisi, E.V.
Deposit date:2017-09-18
Release date:2018-04-25
Last modified:2020-01-01
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Architecture of an HIV-1 reverse transcriptase initiation complex.
Nature, 557, 2018
6CMX
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HUMAN TENEURIN 2 EXTRA-CELLULAR REGION
Descriptor:Teneurin-2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose, ...
Authors:Shalev-Benami, M., Li, J., Sudhof, T., Skiniotis, G., Arac, D.
Deposit date:2018-03-06
Release date:2018-07-25
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.
Cell, 173, 2018
6DDE
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MU OPIOID RECEPTOR-GI PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Koehl, A., Hu, H., Maeda, S., Manglik, A., Zhang, Y., Kobilka, B.K., Skiniotis, G., Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
6DDF
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MU OPIOID RECEPTOR-GI PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Koehl, A., Hu, H., Maeda, S., Manglik, A., Kobilka, B.K., Skiniotis, G., Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
6N4B
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CANNABINOID RECEPTOR 1-G PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Krishna Kumar, K., Shalev-Benami, M., Hu, H., Weis, W.I., Kobilka, B.K., Skiniotis, G.
Deposit date:2018-11-18
Release date:2019-01-30
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Cell, 176, 2019
6N4Y
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METABOTROPIC GLUTAMATE RECEPTOR 5 EXTRACELLULAR DOMAIN WITH NB43
Descriptor:Metabotropic glutamate receptor 5, Nanobody 43, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Koehl, A., Hu, H., Feng, D., Sun, B., Chu, M., Weis, W.I., Mathiesen, J.M., Skiniotis, G., Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.262 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N50
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METABOTROPIC GLUTAMATE RECEPTOR 5 EXTRACELLULAR DOMAIN IN COMPLEX WITH NB43 AND L-QUISQUALIC ACID
Descriptor:Metabotropic glutamate receptor 5, Nanobody 43, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Koehl, A., Hu, H., Feng, D., Sun, B., Chu, M., Weis, W.I., Skiniotis, G., Mathiesen, J.M., Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.751 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6OIJ
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MUSCARINIC ACETYLCHOLINE RECEPTOR 1-G11 PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein subunit alpha-11, Muscarinic acetylcholine receptor M1, Antibody fragment, ...
Authors:Maeda, S., Qianhui, Q., Skiniotis, G., Kobilka, B.
Deposit date:2019-04-09
Release date:2019-05-08
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
Science, 364, 2019
6OIK
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MUSCARINIC ACETYLCHOLINE RECEPTOR 2-GO COMPLEX
Descriptor:Muscarinic acetylcholine receptor M2,Muscarinic acetylcholine receptor M2, Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Maeda, S., Qianhui, Q., Skiniotis, G., Kobilka, B.
Deposit date:2019-04-09
Release date:2019-05-08
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
Science, 364, 2019
6OS9
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HUMAN NEUROTENSIN RECEPTOR 1 (HNTSR1) - GI1 PROTEIN COMPLEX IN CANONICAL CONFORMATION (C STATE)
Descriptor:Neurotensin receptor type 1, JMV449, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Kato, H.E., Zhang, Y., Kobilka, B.K., Skiniotis, G.
Deposit date:2019-05-01
Release date:2019-07-10
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational transitions of a neurotensin receptor 1-Gi1complex.
Nature, 572, 2019
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PDB entries from 2020-09-16