Author results

6OYA
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STRUCTURE OF THE RHODOPSIN-TRANSDUCIN-NANOBODY COMPLEX
Descriptor:Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ...
Authors:Gao, Y., Hu, H., Ramachandran, S., Erickson, J.W., Cerione, R.A., Skiniotis, G.
Deposit date:2019-05-14
Release date:2019-07-24
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Mol.Cell, 75, 2019
6OY9
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STRUCTURE OF THE RHODOPSIN-TRANSDUCIN COMPLEX
Descriptor:Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ...
Authors:Gao, Y., Hu, H., Ramachandran, S., Erickson, J.W., Cerione, R.A., Skiniotis, G.
Deposit date:2019-05-14
Release date:2019-07-24
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Mol.Cell, 75, 2019
6OSA
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HUMAN NEUROTENSIN RECEPTOR 1 (HNTSR1) - GI1 PROTEIN COMPLEX IN NON-CANONICAL CONFORMATION (NC STATE)
Descriptor:Neurotensin receptor type 1, JMV449, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Kato, H.E., Zhang, Y., Kobilka, B.K., Skiniotis, G.
Deposit date:2019-05-01
Release date:2019-07-10
Last modified:2019-08-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational transitions of a neurotensin receptor 1-Gi1complex.
Nature, 572, 2019
6OS9
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HUMAN NEUROTENSIN RECEPTOR 1 (HNTSR1) - GI1 PROTEIN COMPLEX IN CANONICAL CONFORMATION (C STATE)
Descriptor:Neurotensin receptor type 1, JMV449, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Kato, H.E., Zhang, Y., Kobilka, B.K., Skiniotis, G.
Deposit date:2019-05-01
Release date:2019-07-10
Last modified:2019-08-14
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational transitions of a neurotensin receptor 1-Gi1complex.
Nature, 572, 2019
6OIK
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MUSCARINIC ACETYLCHOLINE RECEPTOR 2-GO COMPLEX
Descriptor:Muscarinic acetylcholine receptor M2,Muscarinic acetylcholine receptor M2, Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Maeda, S., Qianhui, Q., Skiniotis, G., Kobilka, B.
Deposit date:2019-04-09
Release date:2019-05-08
Last modified:2019-05-29
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
Science, 364, 2019
6OIJ
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MUSCARINIC ACETYLCHOLINE RECEPTOR 1-G11 PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein subunit alpha-11, Muscarinic acetylcholine receptor M1, Antibody fragment, ...
Authors:Maeda, S., Qianhui, Q., Skiniotis, G., Kobilka, B.
Deposit date:2019-04-09
Release date:2019-05-08
Last modified:2019-05-29
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.
Science, 364, 2019
6N52
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METABOTROPIC GLUTAMATE RECEPTOR 5 APO FORM
Descriptor:Metabotropic glutamate receptor 5, N-ACETYL-D-GLUCOSAMINE
Authors:Koehl, A., Hu, H., Feng, D., Sun, B., Weis, W.I., Skiniotis, G.S., Mathiesen, J.M., Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N51
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METABOTROPIC GLUTAMATE RECEPTOR 5 BOUND TO L-QUISQUALATE AND NB43
Descriptor:Metabotropic glutamate receptor 5, Nanobody 43, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Koehl, A., Hu, H., Feng, D., Sun, B., Weis, W.I., Skiniotis, G.S., Mathiesen, J.M., Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N50
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METABOTROPIC GLUTAMATE RECEPTOR 5 EXTRACELLULAR DOMAIN IN COMPLEX WITH NB43 AND L-QUISQUALIC ACID
Descriptor:Metabotropic glutamate receptor 5, Nanobody 43, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Koehl, A., Hu, H., Feng, D., Sun, B., Chu, M., Weis, W.I., Skiniotis, G., Mathiesen, J.M., Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.751 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N4Y
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METABOTROPIC GLUTAMATE RECEPTOR 5 EXTRACELLULAR DOMAIN WITH NB43
Descriptor:Metabotropic glutamate receptor 5, Nanobody 43, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Koehl, A., Hu, H., Feng, D., Sun, B., Chu, M., Weis, W.I., Mathiesen, J.M., Skiniotis, G., Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.262 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N4X
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METABOTROPIC GLUTAMATE RECEPTOR 5 APO FORM LIGAND BINDING DOMAIN
Descriptor:Metabotropic glutamate receptor 5, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION
Authors:Koehl, A., Hu, H., Feng, D., Sun, B., Weis, W.I., Skiniotis, G.S., Mathiesen, J.M., Kobilka, B.K.
Deposit date:2018-11-20
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural insights into the activation of metabotropic glutamate receptors.
Nature, 566, 2019
6N4B
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CANNABINOID RECEPTOR 1-G PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Krishna Kumar, K., Shalev-Benami, M., Hu, H., Weis, W.I., Kobilka, B.K., Skiniotis, G.
Deposit date:2018-11-18
Release date:2019-01-30
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.
Cell, 176, 2019
6E2H
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CRYSTAL STRUCTURE OF HUMAN ASH2L (SPRY DOMAIN AND SDI MOTIF) IN COMPLEX WITH FULL LENGTH DPY-30
Descriptor:Set1/Ash2 histone methyltransferase complex subunit ASH2, Protein dpy-30 homolog
Authors:Joshi, M., Brunzelle, J.S., Couture, J.F.
Deposit date:2018-07-11
Release date:2018-08-08
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (2.236 Å)
Cite:Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation.
Structure, 26, 2018
6E29
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CRYSTAL STRUCTURE OF MYCELIOPHTERIA_THERMOPHILA CPS50 (SWD1) BETA-PROPELLER DOMAIN
Descriptor:SWD1-like protein
Authors:Joshi, M., Yang, Y., Brunzelle, J.S., Couture, J.F.
Deposit date:2018-07-10
Release date:2018-07-25
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (1.818 Å)
Cite:Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.
Cell, 174, 2018
6DDF
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MU OPIOID RECEPTOR-GI PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Koehl, A., Hu, H., Maeda, S., Manglik, A., Kobilka, B.K., Skiniotis, G., Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
6DDE
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MU OPIOID RECEPTOR-GI PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Koehl, A., Hu, H., Maeda, S., Manglik, A., Zhang, Y., Kobilka, B.K., Skiniotis, G., Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
6CRK
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HETEROTRIMERIC G-PROTEIN IN COMPLEX WITH AN ANTIBODY FRAGMENT
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Maeda, S., Dawson, R., Kobilka, B.
Deposit date:2018-03-19
Release date:2018-10-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Development of an antibody fragment that stabilizes GPCR/G-protein complexes.
Nat Commun, 9, 2018
6CMX
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HUMAN TENEURIN 2 EXTRA-CELLULAR REGION
Descriptor:Teneurin-2, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE
Authors:Shalev-Benami, M., Li, J., Sudhof, T., Skiniotis, G., Arac, D.
Deposit date:2018-03-06
Release date:2018-07-25
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse.
Cell, 173, 2018
6BX3
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STRUCTURE OF HISTONE H3K4 METHYLTRANSFERASE
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-4 specific, COMPASS component BRE2, ...
Authors:Skiniotis, G., Qu, Q.H.
Deposit date:2017-12-16
Release date:2018-09-05
Last modified:2019-12-04
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.
Cell, 174, 2018
6BE6
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ADAM10 EXTRACELLULAR DOMAIN
Descriptor:Disintegrin and metalloproteinase domain-containing protein 10, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Seegar, T.C.M.
Deposit date:2017-10-24
Release date:2017-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10.
Cell, 171, 2017
6BDZ
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ADAM10 EXTRACELLULAR DOMAIN BOUND BY THE 11G2 FAB
Descriptor:11G2 Fab Light Chain, 11G2 Fab Heavy Chain, Disintegrin and metalloproteinase domain-containing protein 10, ...
Authors:Seegar, T.C.M.
Deposit date:2017-10-24
Release date:2017-12-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10.
Cell, 171, 2017
6B19
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ARCHITECTURE OF HIV-1 REVERSE TRANSCRIPTASE INITIATION COMPLEX CORE
Descriptor:reverse transcriptase p66 subunit, reverse transcriptase p51 subunit, RNA genome fragment, ...
Authors:Larsen, K.P., Mathiharan, Y.K., Chen, D.H., Puglisi, J.D., Skiniotis, G., Puglisi, E.V.
Deposit date:2017-09-18
Release date:2018-04-25
Last modified:2018-05-09
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Architecture of an HIV-1 reverse transcriptase initiation complex.
Nature, 557, 2018
6AZ3
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CRYO-EM STRUCTURE OF OF THE LARGE SUBUNIT OF LEISHMANIA RIBOSOME BOUND TO PAROMOMYCIN
Descriptor:ribosomal protein uL2, ribosomal protein uL3, ribosomal protein uL4, ...
Authors:Shalev-Benami, M., Zhang, Y., Rozenberg, H., Nobe, Y., Taoka, M., Matzov, D., Zimmerman, E., Bashan, A., Isobe, T., Jaffe, C.L., Yonath, A., Skiniotis, G.
Deposit date:2017-09-09
Release date:2017-12-06
Last modified:2017-12-13
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Nat Commun, 8, 2017
6AZ1
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CRYO-EM STRUCTURE OF THE SMALL SUBUNIT OF LEISHMANIA RIBOSOME BOUND TO PAROMOMYCIN
Descriptor:Ribosomal protein s1e, ribosomal protein S2, ribosomal protein S3, ...
Authors:Shalev-Benami, M., Zhang, Y., Rozenberg, H., Matzov, D., Zimmerman, E., Bashan, A., Jaffe, C.L., Yonath, A., Skiniotis, G.
Deposit date:2017-09-09
Release date:2017-12-06
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Nat Commun, 8, 2017
5VAI
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CRYO-EM STRUCTURE OF THE ACTIVATED GLUCAGON-LIKE PEPTIDE-1 RECEPTOR IN COMPLEX WITH G PROTEIN
Descriptor:Uncharacterized protein, Glucagon-like peptide 1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
Authors:Zhang, Y., Sun, B., Feng, D., Hu, H., Chu, M., Qu, Q., Tarrasch, J.T., Li, S., Kobilka, T.S., Kobilka, B.K., Skiniotis, G.
Deposit date:2017-03-27
Release date:2017-05-24
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.
Nature, 546, 2017
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