Author results

2G6N
  • Download 2g6n
  • View 2g6n
Molmil generated image of 2g6n
STRCTURE OF RAT NNOS HEME DOMAIN (BH2 BOUND) COMPLEXED WITH CO
Descriptor:Nitric-oxide synthase, brain, ACETATE ION, ...
Authors:Li, H., Igarashi, J., Jamal, J., Yang, W., Poulos, T.L.
Deposit date:2006-02-24
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.
J.Biol.Inorg.Chem., 11, 2006
2G6O
  • Download 2g6o
  • View 2g6o
Molmil generated image of 2g6o
STRUCTURE OF BOVINE ENOS HEME DOMAIN (BH4-FREE) COMPLEXED WITH CO
Descriptor:Nitric-oxide synthase, endothelial, ACETATE ION, ...
Authors:Li, H., Igarashi, J., Jamal, J., Yang, W., Poulos, T.L.
Deposit date:2006-02-24
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of constitutive nitric oxide synthases with diatomic ligands bound.
J.Biol.Inorg.Chem., 11, 2006
2G8F
  • Download 2g8f
  • View 2g8f
Molmil generated image of 2g8f
B. HALODURANS RNASE H CATALYTIC DOMAIN E188A MUTANT IN COMPLEX WITH MG2+ AND RNA/DNA HYBRID (NON-P NICK AT THE ACTIVE SITE)
Descriptor:5'-R(*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-02
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8H
  • Download 2g8h
  • View 2g8h
Molmil generated image of 2g8h
B. HALODURANS RNASE H CATALYTIC DOMAIN D192N MUTANT IN COMPLEX WITH MG2+ AND RNA/DNA HYBRID (NON-P NICK AT THE ACTIVE SITE)
Descriptor:5'-R(*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-02
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8I
  • Download 2g8i
  • View 2g8i
Molmil generated image of 2g8i
B. HALODURANS RNASE H CATALYTIC DOMAIN D192N MUTANT IN COMPLEX WITH MN2+ AND RNA/DNA HYBRID (NON-P NICK AT THE ACTIVE SITE)
Descriptor:5'-R(*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-02
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8K
  • Download 2g8k
  • View 2g8k
Molmil generated image of 2g8k
B. HALODURANS RNASE H CATALYTIC DOMAIN D192N MUTANT IN COMPLEX WITH CA2+ AND RNA/DNA HYBRID (NON-P NICK AT THE ACTIVE SITE)
Descriptor:5'-R(*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-02
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8U
  • Download 2g8u
  • View 2g8u
Molmil generated image of 2g8u
B. HALODURANS RNASE H CATALYTIC DOMAIN D132N MUTANT IN COMPLEX WITH MG2+ AND RNA/DNA HYBRID (NON-P NICK AT THE ACTIVE SITE)
Descriptor:5'-R(*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-03
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8V
  • Download 2g8v
  • View 2g8v
Molmil generated image of 2g8v
B. HALODURANS RNASE H CATALYTIC DOMAIN E188A MUTANT IN COMPLEX WITH MG2+ AND RNA/DNA HYBRID (REACTION PRODUCT)
Descriptor:5'-R(P*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-03
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8W
  • Download 2g8w
  • View 2g8w
Molmil generated image of 2g8w
B. HALODURANS RNASE H CATALYTIC DOMAIN E188A MUTANT IN COMPLEX WITH CA2+ AND RNA/DNA HYBRID
Descriptor:5'-R(P*UP*CP*GP*AP*CP*A)-3', 5'-D(*AP*TP*GP*TP*CP*G)-3', Ribonuclease H, ...
Authors:Nowotny, M., Yang, W.
Deposit date:2006-03-03
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2IMW
  • Download 2imw
  • View 2imw
Molmil generated image of 2imw
MECHANISM OF TEMPLATE-INDEPENDENT NUCLEOTIDE INCORPORATION CATALYZED BY A TEMPLATE-DEPENDENT DNA POLYMERASE
Descriptor:5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*C)-3', 5'-D(*TP*AP*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', DNA polymerase IV, ...
Authors:Ling, H., Yang, W.
Deposit date:2006-10-05
Release date:2007-01-16
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Mechanism of Template-independent Nucleotide Incorporation Catalyzed by a Template-dependent DNA Polymerase.
J.Mol.Biol., 365, 2007
2QK9
  • Download 2qk9
  • View 2qk9
Molmil generated image of 2qk9
HUMAN RNASE H CATALYTIC DOMAIN MUTANT D210N IN COMPLEX WITH 18-MER RNA/DNA HYBRID
Descriptor:5'-R(*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3', 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*T)-3', Ribonuclease H1, ...
Authors:Nowotny, M., Gaidamakov, S.A., Ghirlando, R., Cerritelli, S.M., Crouch, R.J., Yang, W.
Deposit date:2007-07-10
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
2QKB
  • Download 2qkb
  • View 2qkb
Molmil generated image of 2qkb
HUMAN RNASE H CATALYTIC DOMAIN MUTANT D210N IN COMPLEX WITH 20-MER RNA/DNA HYBRID
Descriptor:5'-R(*GP*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3'), 5'-D(*DGP*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*DTP*DGP*DTP*DCP*DGP*DCP*DAP*DCP*DTP*DCP*DT)-3', Ribonuclease H1, ...
Authors:Nowotny, M., Gaidamakov, S.A., Ghirlando, R., Cerritelli, S.M., Crouch, R.J., Yang, W.
Deposit date:2007-07-10
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
2QKK
  • Download 2qkk
  • View 2qkk
Molmil generated image of 2qkk
HUMAN RNASE H CATALYTIC DOMAIN MUTANT D210N IN COMPLEX WITH 14-MER RNA/DNA HYBRID
Descriptor:5'-R(*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3', 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*G)-3', Ribonuclease H1, ...
Authors:Nowotny, M., Gaidamakov, S.A., Ghirlando, R., Cerritelli, S.M., Crouch, R.J., Yang, W.
Deposit date:2007-07-11
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
2QNC
  • Download 2qnc
  • View 2qnc
Molmil generated image of 2qnc
CRYSTAL STRUCTURE OF T4 ENDONUCLEASE VII N62D MUTANT IN COMPLEX WITH A DNA HOLLIDAY JUNCTION
Descriptor:DNA (5'-D(*DCP*DG*DAP*DAP*DGP*DAP*DAP*DTP*DTP*DCP*DCP*DGP*DGP*DAP*DTP*DTP*DAP*DGP*DGP*DGP*DAP*DTP*DCP*DC)-3'), DNA (5'-D(*DGP*DGP*DAP*DTP*DCP*DCP*DCP*DTP*DAP*DAP*DGP*DCP*DTP*DCP*DCP*DAP*DTP*DCP*DGP*DAP*DTP*DGP*DTP*DG)-3'), DNA (5'-D(*DCP*DAP*DCP*DAP*DTP*DCP*DGP*DAP*DTP*DGP*DGP*DAP*DGP*DCP*DCP*DGP*DCP*DTP*DAP*DGP*DGP*DCP*DCP*DT)-3'), ...
Authors:Biertumpfel, C., Yang, W., Suck, D.
Deposit date:2007-07-18
Release date:2008-01-29
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of T4 endonuclease VII resolving a Holliday junction.
Nature, 449, 2007
2QNF
  • Download 2qnf
  • View 2qnf
Molmil generated image of 2qnf
CRYSTAL STRUCTURE OF T4 ENDONUCLEASE VII H43N MUTANT IN COMPLEX WITH HETERODUPLEX DNA CONTAINING BASE MISMATCHES
Descriptor:DNA (5'-D(*DCP*DAP*DCP*DAP*DTP*DCP*DGP*DAP*DTP*DGP*DGP*DAP*DGP*DCP*DCP*DG)-3'), DNA (5'-D(*DGP*DCP*DGP*DCP*DTP*DCP*DCP*DAP*DTP*DCP*DGP*DAP*DTP*DGP*DTP*DG)-3'), DNA (5'-D(*DCP*DGP*DGP*DCP*DTP*DCP*DCP*DAP*DTP*DCP*DGP*DAP*DTP*DGP*DTP*DG)-3'), ...
Authors:Biertumpfel, C., Yang, W., Suck, D.
Deposit date:2007-07-18
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of T4 endonuclease VII resolving a Holliday junction.
Nature, 449, 2007
3BSU
  • Download 3bsu
  • View 3bsu
Molmil generated image of 3bsu
HYBRID-BINDING DOMAIN OF HUMAN RNASE H1 IN COMPLEX WITH 12-MER RNA/DNA
Descriptor:RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3'), DNA (5'-D(*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*(5IU)P*DGP*DTP*DC)-3'), Ribonuclease H1, ...
Authors:Nowotny, M., Cerritelli, S.M., Ghirlando, R., Gaidamakov, S.A., Crouch, R.J., Yang, W.
Deposit date:2007-12-26
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD.
Embo J., 27, 2008
3DJ5
  • Download 3dj5
  • View 3dj5
Molmil generated image of 3dj5
CRYSTAL STRUCTURE OF THE MOUSE AURORA-A CATALYTIC DOMAIN (ASN186->GLY, LYS240->ARG, MET302->LEU) IN COMPLEX WITH COMPOUND 290.
Descriptor:serine/threonine kinase 6, 3-({3-[(6-amino-5-bromopyrimidin-4-yl)sulfanyl]propanoyl}amino)-4-methoxy-N-phenylbenzamide
Authors:Elling, R.A., Erlanson, D.A., Yang, W., Tangonan, B.T., Hansen, S.K., Romanowski, M.J.
Deposit date:2008-06-22
Release date:2009-05-05
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:New fragment-based drug discovery
To be Published
3DJ6
  • Download 3dj6
  • View 3dj6
Molmil generated image of 3dj6
CRYSTAL STRUCTURE OF THE MOUSE AURORA-A CATALYTIC DOMAIN (ASN186->GLY, LYS240->ARG, MET302->LEU) IN COMPLEX WITH COMPOUND 823.
Descriptor:serine/threonine kinase 6, 4-methoxy-N-phenyl-3-({3-[(1H-pyrrolo[2,3-b]pyridin-5-ylmethyl)sulfanyl]propanoyl}amino)benzamide
Authors:Elling, R.A., Erlanson, D.A., Yang, W., Tangonan, B.T., Hansen, S.K., Romanowski, M.J.
Deposit date:2008-06-22
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:New fragment-based drug discovery
To be Published
3DJ7
  • Download 3dj7
  • View 3dj7
Molmil generated image of 3dj7
CRYSTAL STRUCTURE OF THE MOUSE AURORA-A CATALYTIC DOMAIN (ASN186->GLY, LYS240->ARG, MET302->LEU) IN COMPLEX WITH COMPOUND 130.
Descriptor:serine/threonine kinase 6, 1-(5-{2-[(6-amino-5-bromopyrimidin-4-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea
Authors:Elling, R.A., Yang, W., Erlanson, D.A., Tangonan, B.T., Hansen, S.K., Romanowski, M.J.
Deposit date:2008-06-22
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:New fragment-based drug discovery
To be Published
3LWO
  • Download 3lwo
  • View 3lwo
Molmil generated image of 3lwo
STRUCTURE OF H/ACA RNP BOUND TO A SUBSTRATE RNA CONTAINING 5BRU
Descriptor:Pseudouridine synthase Cbf5, Ribosome biogenesis protein Nop10, 50S ribosomal protein L7Ae, ...
Authors:Zhou, J., Liang, B., Lv, C., Yang, W., Li, H.
Deposit date:2010-02-24
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.855 Å)
Cite:Glycosidic bond conformation preference plays a pivotal role in catalysis of RNA pseudouridylation: a combined simulation and structural study.
J.Mol.Biol., 401, 2010
3LWP
  • Download 3lwp
  • View 3lwp
Molmil generated image of 3lwp
STRUCTURE OF H/ACA RNP BOUND TO A SUBSTRATE RNA CONTAINING 5BRDU
Descriptor:Pseudouridine synthase Cbf5, Ribosome biogenesis protein Nop10, 50S ribosomal protein L7Ae, ...
Authors:Zhou, J., Liang, B., Lv, C., Yang, W., Li, H.
Deposit date:2010-02-24
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Glycosidic bond conformation preference plays a pivotal role in catalysis of RNA pseudouridylation: a combined simulation and structural study.
J.Mol.Biol., 401, 2010
3MR2
  • Download 3mr2
  • View 3mr2
Molmil generated image of 3mr2
HUMAN DNA POLYMERASE ETA IN COMPLEX WITH NORMAL DNA AND INCOMING NUCLEOTIDE (NRM)
Descriptor:DNA polymerase eta, DNA (5'-D(*T*CP*AP*TP*TP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*TP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Biertumpfel, C., Zhao, Y., Ramon-Maiques, S., Gregory, M.T., Lee, J.Y., Yang, W.
Deposit date:2010-04-28
Release date:2010-06-30
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010
3MR3
  • Download 3mr3
  • View 3mr3
Molmil generated image of 3mr3
HUMAN DNA POLYMERASE ETA - DNA TERNARY COMPLEX WITH THE 3'T OF A CPD IN THE ACTIVE SITE (TT1)
Descriptor:DNA polymerase eta, DNA (5'-D(*CP*AP*(TTD)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*CP*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Biertumpfel, C., Zhao, Y., Ramon-Maiques, S., Gregory, M.T., Lee, J.Y., Yang, W.
Deposit date:2010-04-28
Release date:2010-06-30
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010
3MR5
  • Download 3mr5
  • View 3mr5
Molmil generated image of 3mr5
HUMAN DNA POLYMERASE ETA - DNA TERNARY COMPLEX WITH A CPD 1BP UPSTREAM OF THE ACTIVE SITE (TT3)
Descriptor:DNA polymerase eta, DNA (5'-D(*TP*AP*AP*CP*(TTD)P*AP*TP*GP*AP*CP*GP*A)-3'), DNA (5'-D(*AP*CP*GP*TP*CP*AP*TP*AP*A)-3'), ...
Authors:Biertumpfel, C., Zhao, Y., Ramon-Maiques, S., Gregory, M.T., Lee, J.Y., Yang, W.
Deposit date:2010-04-28
Release date:2010-06-30
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010
3MR6
  • Download 3mr6
  • View 3mr6
Molmil generated image of 3mr6
HUMAN DNA POLYMERASE ETA - DNA TERNARY COMPLEX WITH A CPD 2BP UPSTREAM OF THE ACTIVE SITE (TT4)
Descriptor:DNA polymerase eta, DNA (5'-D(*C*AP*TP*CP*AP*(TTD)P*AP*CP*GP*AP*GP*C)-3'), DNA (5'-D(*TP*CP*TP*CP*GP*TP*AP*AP*T)-3'), ...
Authors:Biertumpfel, C., Zhao, Y., Ramon-Maiques, S., Gregory, M.T., Lee, J.Y., Yang, W.
Deposit date:2010-04-28
Release date:2010-06-30
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and mechanism of human DNA polymerase eta.
Nature, 465, 2010