Author results

6S13
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ERYTHROMYCIN RESISTANT STAPHYLOCOCCUS AUREUS 70S RIBOSOME (DELTA R88 A89 UL22).
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Halfon, Y., Matozv, D., Eyal, Z., Bashan, A., Zimmerman, E., Kjeldgaard, J., Ingmer, H., Yonath, A.
Deposit date:2019-06-18
Release date:2019-08-21
Method:ELECTRON MICROSCOPY (3.58 Å)
Cite:Exit tunnel modulation as resistance mechanism of S. aureus erythromycin resistant mutant.
Sci Rep, 9, 2019
1NWX
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COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH ABT-773
Descriptor:23S RIBOSOMAL RNA, 5S RIBOSOMAL RNA, ribosomal protein L2, ...
Authors:Schluenzen, F., Harms, J., Franceschi, F., Hansen, H.A.S., Bartels, H., Zarivach, R., Yonath, A.
Deposit date:2003-02-07
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural basis for the antibiotic activity of ketolides and azalides.
Structure, 11, 2003
1NWY
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COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH AZITHROMYCIN
Descriptor:23S RIBOSOMAL RRNA, 5S RIBOSOMAL RRNA, ribosomal protein L2, ...
Authors:Schluenzen, F., Harms, J., Franceschi, F., Hansen, H.A.S., Bartels, H., Zarivach, R., Yonath, A.
Deposit date:2003-02-07
Release date:2003-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis for the antibiotic activity of ketolides and azalides.
Structure, 11, 2003
1SM1
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COMPLEX OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS WITH QUINUPRISTIN AND DALFOPRISTIN
Descriptor:23S RIBOSOMAL RNA, 50S RIBOSOMAL PROTEIN L33, 50S RIBOSOMAL PROTEIN L34, ...
Authors:Harms, J.M., Schluenzen, F., Fucini, P., Bartels, H., Yonath, A.
Deposit date:2004-03-08
Release date:2004-08-03
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Alterations at the Peptidyl Transferase Centre of the Ribosome Induced by the Synergistic Action of the Streptogramins Dalfopristin and Quinupristin.
Bmc Biol., 2, 2004
1XBP
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INHIBITION OF PEPTIDE BOND FORMATION BY PLEUROMUTILINS: THE STRUCTURE OF THE 50S RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS IN COMPLEX WITH TIAMULIN
Descriptor:23S RIBOSOMAL RNA, 5S RIBOSOMAL RNA, 50S ribosomal protein L2, ...
Authors:Schluenzen, F., Pyetan, E., Fucini, P., Yonath, A., Harms, J.M.
Deposit date:2004-08-31
Release date:2005-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin.
Mol.Microbiol., 54, 2004
2O43
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STRUCTURE OF 23S RRNA OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS IN COMPLEX WITH THE MACROLIDE ERYTHROMYCYLAMINE
Descriptor:23S rRNA, (3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-10-AMINO-6-{[(2S,3R,4S,6R)-4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY}-14-ETHYL-7,12,13-TRIHYDROXY-4-{[(2R,4R,5S,6S)-5-HYDROXY-4-METHOXY-4,6-DIMETHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY}-3,5,7,9,11,13-HEXAMETHYLOXACYCLOTETRADECAN-2-ONE
Authors:Pyetan, E., Baram, D., Auerbach-Nevo, T., Yonath, A.
Deposit date:2006-12-03
Release date:2007-12-04
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Chemical parameters influencing fine tuning in the binding of Macrolide antibiotics to the ribosomal tunnel
TO BE PUBLISHED
2O44
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STRUCTURE OF 23S RRNA OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS IN COMPLEX WITH THE MACROLIDE JOSAMYCIN
Descriptor:23S rRNA, (2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-6-{[(4R,5S,6S,7R,9R,10S,12E,14Z,16R)-4-(ACETYLOXY)-10-HYDROXY-5-METHOXY-9,16-DIMETHYL-2-OXO-7-(2-OXOETHYL)OXACYCLOHEXADECA-12,14-DIEN-6-YL]OXY}-4-(DIMETHYLAMINO)-5-HYDROXY-2-METHYLTETRAHYDRO-2H-PYRAN-3-YL]OXY}-4-HYDROXY-2,4-DIMETHYLTETRAHYDRO-2H-PYRAN-3-YL 3-METHYLBUTANOATE
Authors:Pyetan, E., Daram, D., Auerbach-Nevo, T., Yonath, A.
Deposit date:2006-12-03
Release date:2007-12-04
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Chemical parameters influencing fine tuning in the binding of Macrolide antibiotics to the ribosomal tunnel
TO BE PUBLISHED
2O45
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STRUCTURE OF THE 23S RRNA OF THE LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS IN COMPLEX WITH THE MACROLIDE RU-69874
Descriptor:23S rRNA, (3AS,4R,7R,8S,9S,10R,11R,13R,15R,15AR)-4-ETHYL-11-METHOXY-3A,7,9,11,13,15-HEXAMETHYL-2,6,14-TRIOXO-1-[4-(4-PYRIDIN-3-YL-1H-IMIDAZOL-1-YL)BUTYL]-10-{[3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-BETA-D-XYLO-HEXOPYRANOSYL]OXY}TETRADECAHYDRO-2H-OXACYCLOTETRADECINO[4,3-D][1,3]OXAZOL-8-YL 2,6-DIDEOXY-3-C-METHYL-3-O-METHYL-ALPHA-L-RIBO-HEXOPYRANOSIDE
Authors:Baram, D., Pyetan, E., Auerbach-Nevo, T., Yonath, A.
Deposit date:2006-12-03
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Chemical Parameters Influencing Fine Tuning in the Binding of Macrolide Antibiotics to the Ribosomal Tunnel
TO BE PUBLISHED
7LYZ
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PROTEIN MODEL BUILDING BY THE USE OF A CONSTRAINED-RESTRAINED LEAST-SQUARES PROCEDURE
Descriptor:HEN EGG WHITE LYSOZYME
Authors:Moult, J., Yonath, A., Sussman, J., Herzberg, O., Podjarny, A., Traub, W.
Deposit date:1977-05-06
Release date:1977-06-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Protein Model Building by the Use of a Constrained-Restrained Least-Squares Procedure
J.Appl.Crystallogr., 16, 1983
5NGM
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2.9S STRUCTURE OF THE 70S RIBOSOME COMPOSING THE S. AUREUS 100S COMPLEX
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Matzov, D., Aibara, S., Zimmerman, E., Bashan, A., Amunts, A., Yonath, A.
Deposit date:2017-03-18
Release date:2017-10-04
Last modified:2018-11-28
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus.
Nat Commun, 8, 2017
6FXC
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THE CRYO-EM STRUCTURE OF HIBERNATING 100S RIBOSOME DIMER FROM PATHOGENIC STAPHYLOCOCCUS AUREUS
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Matzov, D., Aibara, S., Zimmerman, E., Bashan, A., Kidmose, R., Amunts, A., Yonath, A.
Deposit date:2018-03-08
Release date:2018-03-21
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (6.76 Å)
Cite:The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus.
Nat Commun, 8, 2017
4WF9
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THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH TELITHROMYCIN
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Eyal, Z., Matzov, D., Krupkin, M., Wekselman, I., Zimmerman, E., Rozenberg, H., Bashan, A., Yonath, A.E.
Deposit date:2014-09-14
Release date:2015-10-21
Last modified:2016-01-20
Method:X-RAY DIFFRACTION (3.427 Å)
Cite:Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.
Proc.Natl.Acad.Sci.USA, 112, 2015
4WFA
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THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH LINEZOLID
Descriptor:23S rRNA, 5S rRNA, 50S ribosomal protein L2, ...
Authors:Eyal, Z., Matzov, D., Krupkin, M., Wekselman, I., Zimmerman, E., Rozenberg, H., Bashan, A., Yonath, A.E.
Deposit date:2014-09-14
Release date:2015-10-21
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (3.392 Å)
Cite:Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.
Proc.Natl.Acad.Sci.USA, 112, 2015
4WFB
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THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH BC-3205
Descriptor:23S rRNA, 5S rRNA, 50S ribosomal protein L2, ...
Authors:Eyal, Z., Matzov, D., Krupkin, M., Wekselman, I., Zimmerman, E., Rozenberg, H., Bashan, A., Yonath, A.E.
Deposit date:2014-09-14
Release date:2015-10-21
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (3.43 Å)
Cite:Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.
Proc.Natl.Acad.Sci.USA, 112, 2015
6HMA
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IMPROVED MODEL DERIVED FROM CRYO-EM MAP OF STAPHYLOCOCCUS AUREUS LARGE RIBOSOMAL SUBUNIT
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Eyal, Z., Cimicata, G., Matzov, D., Fox, T., de Val, N., Zimmerman, E., Bashan, A., Yonath, A.
Deposit date:2018-09-12
Release date:2018-11-14
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Improved model derived from cryo-EM map of Staphylococcus aureus large ribosomal subunit
To Be Published
1T1M
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BINDING POSITION OF RIBOSOME RECYCLING FACTOR (RRF) ON THE E. COLI 70S RIBOSOME
Descriptor:dodecamer fragment of double helix from 23S rRNA, 42-mer fragment of double helix from 16S rRNA, ribosome recycling factor
Authors:Agrawal, R.K., Sharma, M.R., Kiel, M.C., Hirokawa, G., Booth, T.M., Spahn, C.M., Grassucci, R.A., Kaji, A., Frank, J.
Deposit date:2004-04-16
Release date:2004-06-15
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (12 Å)
Cite:Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: Functional implications
Proc.Natl.Acad.Sci.USA, 101, 2004
1T1O
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COMPONENTS OF THE CONTROL 70S RIBOSOME TO PROVIDE REFERENCE FOR THE RRF BINDING SITE
Descriptor:dodecamer fragment of double helix from 23S rRNA, 19-mer fragment of the 23S rRNA, 42-mer fragment of double helix from 16S rRNA
Authors:Agrawal, R.K., Sharma, M.R., Kiel, M.C., Hirokawa, G., Booth, T.M., Spahn, C.M., Grassucci, R.A., Kaji, A., Frank, J.
Deposit date:2004-04-16
Release date:2004-06-15
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (12 Å)
Cite:Visualization of ribosome-recycling factor on the Escherichia coli 70S ribosome: Functional implications
Proc.Natl.Acad.Sci.USA, 101, 2004
1APN
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THE CRYSTALLOGRAPHIC STRUCTURE OF METAL-FREE CONCANAVALIN A AT 2.5 ANGSTROMS RESOLUTION
Descriptor:CONCANAVALIN A
Authors:Bouckaert, J., Loris, R., Poortmans, F., Wyns, L.
Deposit date:1995-07-28
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystallographic structure of metal-free concanavalin A at 2.5 A resolution.
Proteins, 23, 1995
2SNS
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STAPHYLOCOCCAL NUCLEASE. PROPOSED MECHANISM OF ACTION BASED ON STRUCTURE OF ENZYME-THYMIDINE 3(PRIME),5(PRIME)-BIPHOSPHATE-CALCIUM ION COMPLEX AT 1.5-ANGSTROMS RESOLUTION
Descriptor:THERMONUCLEASE PRECURSOR, CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE
Authors:Legg, M.J., Cotton, F.A., Hazen Jr., E.E.
Deposit date:1982-05-14
Release date:1982-07-29
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:
Thesis, Texas Agricultural and Mechanical University, 1977
1DOI
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2FE-2S FERREDOXIN FROM HALOARCULA MARISMORTUI
Descriptor:2FE-2S FERREDOXIN, POTASSIUM ION, FE2/S2 (INORGANIC) CLUSTER
Authors:Frolow, F., Harel, M., Sussman, J.L., Shoham, M.
Deposit date:1996-04-08
Release date:1996-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insights into protein adaptation to a saturated salt environment from the crystal structure of a halophilic 2Fe-2S ferredoxin.
Nat.Struct.Biol., 3, 1996
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