Author results

5ZYI
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E16
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-pentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYJ
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E16A
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-pentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol, GLYCEROL
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYK
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E25
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-cyclopentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYL
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E25A
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-cyclopentyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol, GLYCEROL
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
5ZYM
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E25B
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-cyclopentyl-3-[(1~{R},2~{S})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol, GLYCEROL
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-05-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6IEZ
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND B16
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-({4'-pentyl-3'-[2-(pyridin-2-yl)ethyl][1,1'-biphenyl]-4-yl}sulfonyl)ethan-1-ol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-09-18
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6IF0
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND D16
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-({4'-pentyl-3'-[(Z)-2-(pyridin-2-yl)ethenyl][1,1'-biphenyl]-4-yl}sulfonyl)ethan-1-ol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-09-18
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6J0O
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND SC1
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[2-fluoranyl-5-[3-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]phenyl]phenyl]sulfonylethanol, UNKNOWN ATOM OR ION
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2018-12-25
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6J81
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CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND E14
Descriptor:LIPID-TRANSFER PROTEIN CERT, 2-[4-[4-propyl-3-[(1~{S},2~{R})-2-pyridin-2-ylcyclopropyl]phenyl]phenyl]sulfonylethanol
Authors:Suzuki, M., Nakao, N., Ueno, M., Sakai, S., Egawa, D., Hanzawa, H., Kawasaki, S., Kumagai, K., Kobayashi, S., Hanada, K.
Deposit date:2019-01-18
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Natural ligand-nonmimetic inhibitors of the lipid-transfer protein CERT
Commun Chem, 2019
6JIB
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HUMAN MTHFD2 IN COMPLEX WITH DS44960156
Descriptor:Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, 4-(5-oxo-1,5-dihydro-2H-[1]benzopyrano[3,4-c]pyridine-3(4H)-carbonyl)benzoic acid, ...
Authors:Suzuki, M., Matsui, Y., Kawai, J.
Deposit date:2019-02-20
Release date:2019-06-05
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.
Acs Med.Chem.Lett., 10, 2019
6JID
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HUMAN MTHFD2 IN COMPLEX WITH COMPOUND 1
Descriptor:Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, 5-(4-oxo-2-phenyl-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carbonyl)-1,3-dihydro-2H-2lambda~6~,1-benzothiazole-2,2-dione, ...
Authors:Suzuki, M., Matsui, Y., Matsuhashi, N., Kawai, J.
Deposit date:2019-02-20
Release date:2019-06-05
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.
Acs Med.Chem.Lett., 10, 2019
6K0T
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CRYSTAL STRUCTURE OF PPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH DIBENZOOXEPINE DERIVATIVE COMPOUND-17
Descriptor:Peroxisome proliferator-activated receptor gamma, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, 3-[(1~{E})-1-[8-[(8-chloranyl-2-cyclopropyl-imidazo[1,2-a]pyridin-3-yl)methyl]-3-fluoranyl-6~{H}-benzo[c][1]benzoxepin-11-ylidene]ethyl]-4~{H}-1,2,4-oxadiazol-5-one
Authors:Suzuki, M., Yamamoto, K., Takahashi, Y., Saito, J.
Deposit date:2019-05-07
Release date:2019-10-30
Last modified:2019-11-06
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Development of a novel class of peroxisome proliferator-activated receptor (PPAR) gamma ligands as an anticancer agent with a unique binding mode based on a non-thiazolidinedione scaffold.
Bioorg.Med.Chem., 27, 2019
7BTV
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CRYSTAL STRUCTURE OF EHMT2 SET DOMAIN IN COMPLEX WITH COMPOUND 5.
Descriptor:Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ...
Authors:Suzuki, M., Mizuno, T., Katayama, K.
Deposit date:2020-04-03
Release date:2020-11-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines.
Bioorg.Med.Chem.Lett., 30, 2020
7BUC
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CRYSTAL STRUCTURE OF EHMT2 SET DOMAIN IN COMPLEX WITH COMPOUND 13
Descriptor:Histone-lysine N-methyltransferase EHMT2, ZINC ION, S-ADENOSYLMETHIONINE, ...
Authors:Suzuki, M., Mizuno, M., Katayama, K.
Deposit date:2020-04-06
Release date:2020-11-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines.
Bioorg.Med.Chem.Lett., 30, 2020
7C61
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CRYSTAL STRUCTURE OF 5-HT1B-BRIL AND SRP2070_FAB COMPLEX
Descriptor:IGG LIGHT CHAIN, IGG HEAVY CHAIN, 5-hydroxytryptamine receptor 1B,Soluble cytochrome b562,5-hydroxytryptamine receptor 1B, ...
Authors:Suzuki, M., Miyagi, H., Asada, H., Yasunaga, M., Suno, C., Takahashi, Y., Saito, J., Iwata, S.
Deposit date:2020-05-21
Release date:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:The discovery of a new antibody for BRIL-fused GPCR structure determination.
Sci Rep, 10, 2020
7C6A
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CRYSTAL STRUCTURE OF AT2R-BRIL AND SRP2070_FAB COMPLEX
Descriptor:IgG Light Chain, IgG heavy chain, Type-2 angiotensin II receptor,Soluble cytochrome b562,Type-2 angiotensin II receptor, ...
Authors:Suzuki, M., Miyagi, H., Asada, H., Yasunaga, M., Suno, C., Takahashi, Y., Saito, J., Iwata, S.
Deposit date:2020-05-21
Release date:2020-07-29
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The discovery of a new antibody for BRIL-fused GPCR structure determination.
Sci Rep, 10, 2020
1V3X
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FACTOR XA IN COMPLEX WITH THE INHIBITOR 1-[6-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO(5,4-C)PYRIDIN-2-YL] CARBONYL-2-CARBAMOYL-4-(6-CHLORONAPHTH-2-YLSULPHONYL)PIPERAZINE
Descriptor:Coagulation factor X, HEAVY CHAIN, LIGHT CHAIN, ...
Authors:Suzuki, M.
Deposit date:2003-11-07
Release date:2004-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element
J.Med.Chem., 47, 2004
2F08
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CRYSTAL STRUCTURE OF A MAJOR HOUSE DUST MITE ALLERGEN, DERF 2
Descriptor:mite allergen Der f II, O-ACETALDEHYDYL-HEXAETHYLENE GLYCOL
Authors:Mikami, B., Tanaka, Y., Minato, N., Suzuki, M., Korematsu, S.
Deposit date:2005-11-12
Release date:2005-11-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure and some properties of a major house dust mite allergen, Derf 2
Biochem.Biophys.Res.Commun., 339, 2006
3IIT
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FACTOR XA IN COMPLEX WITH A CIS-1,2-DIAMINOCYCLOHEXANE DERIVATIVE
Descriptor:Activated factor Xa heavy chain, Factor X light chain, CALCIUM ION, ...
Authors:Suzuki, M.
Deposit date:2009-08-03
Release date:2010-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Bioorg.Med.Chem., 17, 2009
4QBJ
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CRYSTAL STRUCTURE OF N-MYRISTOYL TRANSFERASE FROM ASPERGILLUS FUMIGATUS COMPLEXED WITH A SYNTHETIC INHIBITOR
Descriptor:Glycylpeptide N-tetradecanoyltransferase, SULFATE ION, S-(2-OXO)PENTADECYLCOA, ...
Authors:Suzuki, M., Shimada, T.
Deposit date:2014-05-08
Release date:2015-04-01
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of N-myristoyltransferase from Aspergillus fumigatus
Acta Crystallogr.,Sect.D, 71, 2015
6KKA
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XYLANASE J MUTANT FROM BACILLUS SP. 41M-1
Descriptor:Endo-1,4-beta-xylanase, CALCIUM ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Suzuki, M., Takita, T., Nakatani, K.
Deposit date:2019-07-24
Release date:2019-09-04
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Increase in the thermostability of GH11 xylanase XynJ from Bacillus sp. strain 41M-1 using site saturation mutagenesis.
Enzyme.Microb.Technol., 130, 2019
7C6B
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CRYSTAL STRUCTURE OF AGO2 MID DOMAIN IN COMPLEX WITH 6-(3-(2-CARBOXYETHYL)PHENYL)PURINE RIBOSIDE MONOPHOSPHATE
Descriptor:Protein argonaute-2, 3-[3-[9-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]phenyl]propanoic acid, PHOSPHATE ION
Authors:Suzuki, M., Takahashi, Y., Saito, J., Miyagi, H., Shinohara, F.
Deposit date:2020-05-21
Release date:2020-11-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand.
Rna, 2020
7CPK
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XYLANASE R FROM BACILLUS SP. TAR-1
Descriptor:Endo-1,4-beta-xylanase A, (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, ...
Authors:Kuwata, K., Suzuki, M., Takita, T., Nakatani, K., Li, T., Katano, Y., Kojima, K., Mizutani, K., Mikami, B., Yatsunami, R., Nakamura, S., Yasukawa, K.
Deposit date:2020-08-07
Release date:2020-09-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insight into the mechanism of thermostabilization of Bacillus sp. strain TAR-1 xylanase by the mutation of Ser92 to Glu
to be published
7CPL
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XYLANASE R FROM BACILLUS SP. TAR-1
Descriptor:Endo-1,4-beta-xylanase A, (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, ...
Authors:Kuwata, K., Suzuki, M., Takita, T., Nakatani, K., Li, T., Katano, Y., Kojima, K., Mizutani, K., Mikami, B., Yatsunami, R., Nakamura, S., Yasukawa, K.
Deposit date:2020-08-07
Release date:2020-09-02
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Insight into the mechanism of thermostabilization of Bacillus sp. strain TAR-1 xylanase by the mutation of Ser92 to Glu
to be published
7D7U
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CRYSTAL STRUCTURE OF AGO2 MID DOMAIN IN COMPLEX WITH 8-BR-ADENOSIN-5'-MONOPHOSPHATE
Descriptor:Protein argonaute-2, 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE
Authors:Suzuki, M., Takahashi, Y., Saito, J., Miyagi, H., Shinohara, F.
Deposit date:2020-10-06
Release date:2020-11-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand.
Rna, 2020
171588
PDB entries from 2020-11-25